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PRKAR2A — RNF19A
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Park et al., Neurosci Lett 2000
:
Here we demonstrate that
PKA is
required for depolarization induced activation of both extracellular signal regulated kinase ( ERK ) and
p38 mitogen activated protein ( MAP ) kinase in PC12 cells
Schulte et al., Exp Cell Res 2003
:
Inhibition of cAMP dependent
protein kinase (PKA) using H89 ( N- [ 2- ( ( p-bromocinnamyl ) amino ) ethyl ] -5-isoquinolinesulfonamide ) )
blocked phosphorylation of the cAMP response element binding protein ( CREB ) and
p38 , but did not decrease NECA induced ERK1/2 phosphorylation
Hildesheim et al., J Biol Chem 2005
(Adenomatous Polyposis Coli...) :
Moreover, lack of normal
p38 MAPK activity in either Gadd45a-null keratinocytes or in p38 MAPK inhibitor treated keratinocytes leads to decreased CK2 activity and
increased PKA activity
Chen et al., Cancer Res 2007
(Breast Neoplasms) :
Taken together, PGE ( 2 )
activation of
p38 and JNK1 via
PKA and PKC is necessary for aromatase induction in BAFs, and p38 and JNK1 are potential new drug targets for tissue-specific ablation of aromatase expression in breast cancer
McAlees et al., Mol Cell Biol 2009
:
beta ( 2 ) AR agonists, cAMP elevating agents, and PKA inhibitors were used to show that beta ( 2 ) AR stimulation resulted in a
PKA dependent increase in
p38 MAPK phosphorylation