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CCND2 — CDK2

Pathways - manually collected, often from reviews:

• WikiPathways miRNA Regulation of DNA Damage Response: Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5 → Complex of CDK2-CCNE2-CCNE1 (inhibition)
  
• WikiPathways DNA Damage Response: Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5 → Complex of CDK2-CCNE2-CCNE1 (inhibition)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CCND2 — CDK2 (physical association, affinity chromatography technology) Sweeney et al., Oncogene 1997*
• IRef Biogrid Interaction: CCND2 — CDK2 (physical association, affinity chromatography technology) Varjosalo et al., Nat Methods 2013
• Gene Ontology Complexes cyclin-dependent protein kinase holoenzyme complex: cyclin-dependent protein kinase holoenzyme complex complex (CDK2-CCND2-CDKN1A-CDK6) Ruas et al., Mol Cell Biol 2007*, Wang et al., Cell Struct Funct 2008*, Meyerson et al., Mol Cell Biol 1994*, Reardon et al., Proc Natl Acad Sci U S A 1996
• IRef Intact Interaction: CCND2 — CDK2 (physical association, two hybrid) Zariwala et al., Oncogene 1998

Text-mined interactions from Literome

Coller et al., Proc Natl Acad Sci U S A 2000 : Among the cell cycle genes identified as targets, the G1 cyclin D2 and the cyclin dependent kinase binding protein CksHs2 were induced whereas the cyclin dependent kinase inhibitor p21 ( Cip1 ) was repressed
Rylski et al., Mol Cell Biol 2003 : GATA-1 inhibited expression of cyclin dependent kinase (Cdk) 6 and cyclin D2 and induced the Cdk inhibitors p18(INK4C) and p27 ( Kip1 ) with associated inactivation of all G ( 1 ) Cdks
Sweeney et al., Oncogene 1997 (Breast Neoplasms) : The cyclin D2-associated kinase activity was largely inhibited by Cdk2-specific inhibitors and could phosphorylate histone H1, a substrate for Cdk2 but not for Cdk4 and Cdk6 ... Therefore, cyclin D2 preferentially activated Cdk2 in breast epithelial cells