Akbari et al., Mucosal Immunol 2010
(Asthma) :
As PD-L2 is not expressed on iNKT cells but rather is expressed on lung dendritic cells (DCs), in which its expression is upregulated by allergen challenge or IL-4, these findings suggest an important role of PD-L2 on lung DCs in modulating asthma pathogenesis
Eken et al., Clinical and vaccine immunology : CVI 2011
:
More importantly, ethanol exposed DCs had reduced B7-DC and enhanced ICOS-L ( inhibitory ) costimulatory molecule expression
Lewkowich et al., Mucosal Immunol 2013
:
Decreased AHR was associated with enhanced serum interleukin (IL)-12 p40, and in vitro stimulation of DCs with allergen and PD-L2-Fc reduced IL-12 p70 production, suggesting that PD-L2 inhibits allergen-driven IL-12 production