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AVP — CA1
Text-mined interactions from Literome
Breyer et al., J Clin Invest 1991
:
Because maneuvers that increase [ Ca++]i inhibit Na+ transport, the effects of AVP and cell-permeable cAMP analogues, on [ Ca++]i were investigated in fura-2 loaded in vitro microperfused rabbit CCDs. Low-dose AVP ( 23-230 pM ) selectively stimulated Ca++ influx, whereas 23 nM
AVP additionally released calcium from intracellular stores. 8-chlorophenylthio-cAMP ( 8CPTcAMP ) and 8-bromo-cAMP ( 8-Br-cAMP ) also
increased CCD [
Ca++]i
Jung et al., Biochem Biophys Res Commun 1991
:
Moreover, pretreatment with both V1 and V2 antagonists in MTAL or OMCT completely inhibited the
AVP induced [
Ca++]i transient, but in S1 partially blocked it
Quinn et al., Endocrinology 1990
:
Cytosolic
calcium (Cai) responses to
arginine vasopressin (AVP) and angiotensin-II (Ang II) were examined in single rat adrenal zona glomerulosa ( ZG ) cells by monitoring fura-2 fluorescence with microspectrofluorimetry
Burnatowska-Hledin et al., Am J Physiol 1987
:
The
AVP induced increase in [
Ca]i from 61 +/- 6 to 225 +/- 44 nM ( n = 7, P less than 0.01 ) was rapid and transient, returning to base line in 2 to 3 min ... In MDCK cells, BK, but not
AVP and PTH,
increased [
Ca]i from 146 +/- 11 to 281 +/- 31 nM ( n = 9, P less than 0.001 )
Chen et al., J Pharmacol Exp Ther 1994
(Insulinoma) :
At 8 microM, U-73122 abolished
AVP 's
effect on IP3 and [
Ca++]i , but AVP induced increases in insulin secretion were only reduced by 35 %
Gao et al., Endocrinology 1994
:
In the presence of 15 mM glucose and 2.5 mM Ca2+,
AVP and ACh stimulated inositol phosphate ( IP ) formation,
increased cytoplasmic Ca2+ (Cai2+) , and potentiated insulin release ... Under these conditions, the
effects of
AVP and ACh on IP production and
Cai2+ were practically abolished, and only ACh transiently increased insulin release
Chiodera et al., Eur J Clin Invest 1997
:
These data demonstrate that
AVP secretion is
stimulated by a slight rapid increase in serum
Cai levels even though absolute serum Cai levels remain within the normal range ... In addition, the positive correlation between
Cai induced ACTH and
AVP increments suggests that AVP plays a releasing role on ACTH secretion during calcium infusion
Touyz et al., J Pharmacol Exp Ther 1998
(Hypertension) :
Basal and
AVP stimulated [
Ca++]i responses were significantly increased ( p < .05 ) in SHR ( pD2 = 8.3 +/- 0.1, Emax = 532 +/- 14 nM for SHR ; pD2 = 8.0 +/- 0.04, Emax = 480 +/- 15 nM for WKY ) ... These findings demonstrate that Mg++ dose-dependently reduces [ Ca++]i and that high [ Mg++ ] e attenuates
AVP stimulated [
Ca++]i responses and normalizes sensitivity to AVP in SHR