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KITLG — PIK3CA
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
PIK3CA
→
KITLG
(indirect_complex)
Chian et al., Blood 2001*, Rönnstrand et al., Cell Mol Life Sci 2004*, Reber et al., Eur J Pharmacol 2006, Sun et al., J Biol Chem 2008
-
Reactome Reaction:
PIK3CA
→
KITLG
(reaction)
Chian et al., Blood 2001*, Rönnstrand et al., Cell Mol Life Sci 2004*, Reber et al., Eur J Pharmacol 2006, Sun et al., J Biol Chem 2008
Text-mined interactions from Literome
Sui et al., Br J Haematol 2000
:
Interestingly, both EPO and
SCF induced activation of
PI3K
Chian et al., Blood 2001
(Cell Transformation, Neoplastic) :
SCF stimulates association of
p85PI3K with phosphorylated tyrosine 721 of wild-type c-Kit
Krystal et al., Mol Cancer Ther 2002
(Carcinoma, Small Cell...) :
Both
stem cell factor (SCF) and insulin-like growth factor (IGF)-I, components of prominent small cell lung cancer ( SCLC ) autocrine loops, as well as FCS, can potently
activate phosphatidylinositol 3-kinase
(PI3K)-Akt signaling, albeit with different kinetics ...
SCF induced
PI3K-Akt activation occurs rapidly but fades within 60 min ; IGF-I and FCS induced activation persists for at least 6 h. SCF and IGF-I mediated growth was potently inhibited by LY294002 in proportion to its ability to inhibit phosphatidylinositol 3-kinase (PI3K)-Akt signaling
Jeon et al., Pigment Cell Melanoma Res 2009
:
Stem cell factor induces ERM proteins phosphorylation through
PI3K activation to mediate melanocyte proliferation and migration