Oh et al., Biochem Biophys Res Commun 2004
:
NO produced by iNOS suppresses IDO expression and also induces HO-1 expression
Hill et al., FASEB J 2005
(Breast Neoplasms...) :
Since we also demonstrate that IDO inhibits the anti-proliferative HO-1 , we propose that IDO has opposite effects on proliferation depending on the coexpression or not of HO-1 ... We also describe that HO-1 inhibits IDO at the post-translational level through heme starvation
Jung et al., Biochem Pharmacol 2010
:
In this study, we examined the role of HO-1 in dendritic cell ( DC ) maturation and expression of indoleamine 2,3-dioxygenase (IDO) , a key enzyme that catalyzes the initial, rate limiting step in tryptophan degradation