OpenBEL Selventa BEL large corpus:
MDM2
→
EP300
(increases, EP300 Activity)
Evidence: In addition, p300-deficient (p300(-)) cells fail to undergo G(1)/S arrest after UV irradiation. These abnormalities are associated with prolongation of p53 stability, reduced p53-acetylation, blunting of MDM2 activation, failure to transactivate p21, and a disproportionate increase in PUMA levels.