Meng et al., Proc Natl Acad Sci U S A 2007
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Pak1 dependent phosphorylation of PCBP1 released its binding and translational inhibition from a DICE-minigene ... We also found that Pak1 activation led to an increased nuclear retention of PCBP1 , recruitment to the eukaryotic translation initiation factor 4E ( eIF4E ) promoter, and stimulation of eIF4E expression in a Pak1-sensitive manner
Choi et al., Biochem Biophys Res Commun 2009
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For example, activation by p21 activated kinase 1 induces increased nuclear retention of PCBP1 , as well as increased promoter activity