UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to ROCK1

ITGB3 — ROCK1

Pathways - manually collected, often from reviews:

NCI Pathway Database Integrins in angiogenesis: Hsp90 (HSP90AA1) → VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) (modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
NCI Pathway Database Integrins in angiogenesis: ROCK (ROCK1) → alphav/beta3 Integrin complex (ITGAV-ITGB3) (modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
NCI Pathway Database Integrins in angiogenesis: ROCK (ROCK1) → VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) (modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin complex (ITGAV-ITGB3) → VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) (modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
NCI Pathway Database Integrins in angiogenesis: VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) → VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA) (modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
NCI Pathway Database Integrins in angiogenesis: VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) → RhoA (RHOA) (modification, collaborate) Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
NCI Pathway Database Integrins in angiogenesis: VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) → FAK (PTK2) (modification, activates) Le Boeuf et al., Mol Biol Cell 2006, Abedi et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction