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ERBB2 — SHC1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SHC1 → ERBB2 (increases, SHC1 Activity) Qiu et al., Nature 1998*
  Evidence: Modified assertion
• OpenBEL Selventa BEL large corpus: Complex of ERBB2-SHC1 → IL6 (increases) Qiu et al., Nature 1998*
  Evidence: Two tyrosine-phosphorylated proteins around 190K are co-precipitated with Shc in IL-6-treated cells. These two proteins can be recognized by ErbB2 and ErbB3 antibodies, respectively (Fig. 1c),
• BioCarta trefoil factors initiate mucosal healing: TFFs/ErbB1/ERBB2 complex (EGFR-ERBB2-TFF3_TFF2_TFF1) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta role of erbb2 in signal transduction and oncology: ERBB ligand/ERBB2/ERBB 1/3/4 complex (ERBB2-ERBB4_ERBB3_EGFR) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• KEGG Focal adhesion: EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• KEGG ErbB signaling pathway: Complex of ERBB2 → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• KEGG ErbB signaling pathway: Complex of ERBB2-ERBB3 → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• KEGG ErbB signaling pathway: Complex of ERBB2-ERBB4 → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• NCI Pathway Database ErbB2/ErbB3 signaling events: None → ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 complex (ERBB2-ERBB3-NRG1-SHC1-GRB2-SOS1) (modification, collaborate)
  Goodearl et al., Dev Neurosci 2001
  Evidence: mutant phenotype, assay
• NCI Pathway Database ErbB2/ErbB3 signaling events: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 complex (ERBB2-ERBB3-NRG1-SHC1-GRB2-SOS1) (modification, collaborate)
  Goodearl et al., Dev Neurosci 2001
  Evidence: mutant phenotype, assay
• NCI Pathway Database ErbB2/ErbB3 signaling events: ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 complex (ERBB2-ERBB3-NRG1-SHC1-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Goodearl et al., Dev Neurosci 2001
  Evidence: mutant phenotype, assay
• NCI Pathway Database ErbB2/ErbB3 signaling events: ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 complex (ERBB2-ERBB3-NRG1-SHC1-GRB2-SOS1) → None (modification, activates) Goodearl et al., Dev Neurosci 2001
  Evidence: mutant phenotype, assay
• NCI Pathway Database ErbB2/ErbB3 signaling events: ErbB2/ErbB3/neuregulin 1 beta complex (ERBB2-ERBB3-NRG1) → ErbB2/ErbB3/neuregulin 1 beta/SHC complex (ERBB2-ERBB3-NRG1-SHC1) (modification, collaborate)
  Vijapurkar et al., J Biol Chem 1998, Olayioye et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ErbB2/ErbB3 signaling events: ErbB2/ErbB3/neuregulin 1 beta complex (ERBB2-ERBB3-NRG1) → SHC (SHC1) (modification, collaborate) Vijapurkar et al., J Biol Chem 1998, Olayioye et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ErbB2/ErbB3 signaling events: ErbB2/ErbB3/neuregulin 1 beta/SHC complex (ERBB2-ERBB3-NRG1-SHC1) → SHC (SHC1) (modification, collaborate) Vijapurkar et al., J Biol Chem 1998, Olayioye et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ErbB2/ErbB3 signaling events: SHP2 (PTPN11) → ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 complex (ERBB2-ERBB3-NRG1-SHC1-GRB2-SOS1) (modification, inhibits)
  Tanowitz et al., J Neurosci 1999, Goodearl et al., Dev Neurosci 2001, Vijapurkar et al., J Biol Chem 1998, Olayioye et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB2/ErbB3 signaling events: SHP2 (PTPN11) → ErbB2/ErbB3/neuregulin 1 beta/SHC complex (ERBB2-ERBB3-NRG1-SHC1) (modification, inhibits)
  Tanowitz et al., J Neurosci 1999, Goodearl et al., Dev Neurosci 2001, Vijapurkar et al., J Biol Chem 1998, Olayioye et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB2/ErbB3 signaling events: ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 complex (ERBB2-ERBB3-NRG1-SHC1-GRB2-SOS1) → ErbB2/ErbB3/neuregulin 1 beta/SHC complex (ERBB2-ERBB3-NRG1-SHC1) (modification, collaborate)
  Tanowitz et al., J Neurosci 1999, Goodearl et al., Dev Neurosci 2001, Vijapurkar et al., J Biol Chem 1998, Olayioye et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB2/ErbB3 signaling events: ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 complex (ERBB2-ERBB3-NRG1-SHC1-GRB2-SOS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Tanowitz et al., J Neurosci 1999, Goodearl et al., Dev Neurosci 2001, Vijapurkar et al., J Biol Chem 1998, Olayioye et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB2/ErbB3 signaling events: ErbB2/ErbB3/neuregulin 1 beta/SHC complex (ERBB2-ERBB3-NRG1-SHC1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Tanowitz et al., J Neurosci 1999, Goodearl et al., Dev Neurosci 2001, Vijapurkar et al., J Biol Chem 1998, Olayioye et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction
• Reactome Reaction: ERBB2 → SHC1 (indirect_complex) Kaushansky et al., Chem Biol 2008, Soler et al., Oncogene 1994, Segatto et al., Oncogene 1993, Cohen et al., J Biol Chem 1996, Pinkas-Kramarski et al., EMBO J 1996
• Reactome Reaction: ERBB2 → SHC1 (reaction) Kaushansky et al., Chem Biol 2008, Soler et al., Oncogene 1994, Segatto et al., Oncogene 1993, Cohen et al., J Biol Chem 1996, Pinkas-Kramarski et al., EMBO J 1996
• WikiPathways Focal Adhesion: BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1 → SHC1/SHC3 (activation)
• WikiPathways Association Between Physico-Chemical Features and Toxicity Associated Pathways: ERBB2 → SHC1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: ERBB2 — SHC1 (affinity chromatography technology) Schulze et al., Molecular systems biology 2005
• IRef Biogrid Interaction: SHC1 — ERBB2 (physical association, affinity chromatography technology) Crovello et al., J Biol Chem 1998
• IRef Biogrid Interaction: SHC1 — ERBB2 (direct interaction, unspecified method) Jones et al., Nature 2006
• IRef Biogrid Interaction: SHC1 — ERBB2 (physical association, affinity chromatography technology) Schulze et al., Molecular systems biology 2005
• IRef Biogrid Interaction: SHC1 — ERBB2 (physical association, affinity chromatography technology) Wong et al., J Biol Chem 1999*
• IRef Biogrid Interaction: SHC1 — ERBB2 (physical association, affinity chromatography technology) Olayioye et al., Mol Cell Biol 1998
• MIPS CORUM ERBB2-MEMO-SHC complex: ERBB2-MEMO-SHC complex complex (ERBB2-MEMO1-SHC1) Marone et al., Nat Cell Biol 2004*
• IRef Corum Interaction: Complex of ERBB2-SHC1-MEMO1 (association, coimmunoprecipitation) Marone et al., Nat Cell Biol 2004*
• IRef Hprd Interaction: SHC1 — ERBB2 (in vitro) Schulze et al., Molecular systems biology 2005, Wang et al., Cancer Cell 2006, Olayioye et al., Mol Cell Biol 1998
• IRef Hprd Interaction: SHC1 — ERBB2 (in vivo) Schulze et al., Molecular systems biology 2005, Wang et al., Cancer Cell 2006, Olayioye et al., Mol Cell Biol 1998
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Schulze et al., Molecular systems biology 2005
• IRef Intact Interaction: ERBB2 — SHC1 (physical association, pull down) Schulze et al., Molecular systems biology 2005
• IRef Intact Interaction: ERBB2 — SHC1 (direct interaction, protein array) Jones et al., Nature 2006
• IRef Intact Interaction: Complex of 23 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005
• IRef Intact Interaction: Complex of 14 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 26 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of UBASH3B-CDC37-EGFR-ERBB3-ERRFI1-SHC1-ERBB2-STAT3 (association, anti bait coimmunoprecipitation) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 13 proteins (association, pull down) Wang et al., Cancer Cell 2006
• IRef Intact Interaction: Complex of 70 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005
• IRef Intact Interaction: Complex of PIK3R1-SHC1-ERBB2-ERBB3-EGFR (association, pull down) Wang et al., Cancer Cell 2006
• IRef Ophid Interaction: ERBB2 — SHC1 (aggregation, confirmational text mining) Jones et al., Nature 2006
• IRef Ophid Interaction: ERBB2 — SHC1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Stevenson et al., Breast Cancer Res Treat 1998 (Breast Neoplasms) : Consistent with Shc tyrosine phosphorylation being driven by ErbB2, an ErbB2-specific tyrosine kinase inhibitor markedly reduced Shc tyrosine phosphorylation
Harris et al., Int J Cancer 1999 (Breast Neoplasms...) : Over-expression of ErbB-2 also resulted in the ligand independent constitutive association between Shc and another adaptor protein, Grb2, indicating that receptor activation was sufficient to activate downstream signalling pathways