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EPHB2 — NR1I3

Text-mined interactions from Literome

Handlogten et al., American journal of physiology. Renal physiology 2000 : We analyzed the kinetics of activation of p42ERK and PLA(2) by the CaR in response to Ca ( 2+ ), Co ( 2+ ), and Pb ( 2+ )
Awata et al., J Biol Chem 2001 : The functional importance of their interaction was documented by transiently expressing the CaR in M2 melanoma cells that lack filamin, or in A7 melanoma cells that stably express filamin, and demonstrating that the CaR activated ERK only in the presence of filamin
Corbetta et al., J Clin Endocrinol Metab 2002 (Adenoma...) : In conclusion, these data first demonstrate that CaR activation, through the PKC pathway and, to a lesser extent, PI3K, increases ERK1 and -2 activity in normal parathyroid cells and this cascade seems to be involved in the modulation of PTH secretion by Ca ( o ) ( 2+ )
Holstein et al., J Biol Chem 2004 (MAP Kinase Signaling System) : CaR dependent ERK1/2 activation begins to desensitize to 4 mm Ca ( 2+ ) after 10 min, whereas there is no desensitization to NPS R-467/CaCl ( 2 ) as late as 4 h
Tfelt-Hansen et al., Growth Factors 2005 (MAP Kinase Signaling System...) : The CaR induced activation of ERK1/2 , induction of PTHrP release and stimulation of cellular proliferation in H-500 cells are likewise mediated, in large part, through the EGFR
Davies et al., Am J Physiol Cell Physiol 2006 : Cotreatment with the Rho kinase inhibitors Y-27632 and H1152 attenuated the CaR induced morphological change but not intracellular Ca2+ ( Ca2+ ( i ) ) mobilization or ERK activation, although transfection with a dominant negative RhoA binding protein also inhibited calcimimetic induced actin stress fiber assembly
Lee et al., Biochem J 2007 : Taken together, the data indicate that L-phenylalanine and other amino acids enhance the Ca2+o-sensitivity of CaR stimulated ERK1/2 phosphorylation ; however, the effect is comparatively small and operates in the form of a fine tuning mechanism
Reyes-Ibarra et al., Mol Endocrinol 2007 (Calcium Signaling) : Interestingly, this Rab11a dominant negative mutant does not interfere with CaR dependent activation of ERK 1/2, suggesting that ERK signaling is not sufficient to promote PTHrP secretion downstream of CaR