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PDGFB — PTK2

Text-mined interactions from Literome

Sundberg et al., J Biol Chem 2003 : Instead, FRNK expression markedly attenuated PDGF-BB- , angiotensin II-, and integrin stimulated Rac1 activity and attenuates downstream signaling to JNK
McArthur et al., Semin Oncol 2004 (Dermatofibrosarcoma...) : The resultant deregulated expression of PDGFB leads to continuous activation of the PDGF receptor beta ( PDGFRbeta ) protein-tyrosine kinase that promotes DFSP tumor cell growth
Abedi et al., J Biol Chem 1995 : In contrast, PDGF-BB induced a rapid and concentration dependent increase in p125 focal adhesion kinase (p125FAK) tyrosine phosphorylation, which was half-maximal and maximum at 1 and 2.5 ng/ml, respectively ... PDGF-BB also induced p125FAK and paxillin tyrosine phosphorylation in human aortic VSMC ... In Swiss 3T3 fibroblasts, PDGF-BB and -AA stimulated p125FAK tyrosine phosphorylation and cell migration only at low concentrations, and stimulation was abolished at 10-25 ng/ml. PDGF-AA failed to stimulate tyrosine phosphorylation, mitogenesis, and chemotaxis in rabbit VSMC, and immunoblot analysis showed that rabbit VSMC expressed PDGF beta-receptors but no alpha-receptors
Broome et al., Oncogene 1997 : Treatment of quiescent NIH3T3 cells with PDGF BB results in the transient activation and hyperphosphorylation of the protein-tyrosine kinase , c-Src