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IL1RN — TNF

Text-mined interactions from Literome

Axtelle et al., J Endotoxin Res 2001 (Sepsis) : IC14 inhibited the release of TNF-alpha , IL-6, and IL-10 and delayed the release of sTNFR ( I ) and IL-1ra
Maneiro et al., J Rheumatol 2001 (Osteoarthritis, Knee) : IL-1, TNF-alpha , and LPS produced dose dependent increases in synthesis of IL-1Ra
Stuyt et al., Cytokine 2003 : S. epidermidis induced TNF-alpha was inhibited by IL-18BP and IL-1Ra , but not anti-IL-12 Ab, whereas IL-8 production was unaffected by any of the specific cytokine blocking agents
Patten et al., Naunyn Schmiedebergs Arch Pharmacol 2003 : Interestingly, both, the IL-1beta- and TNFalpha-effect could be blocked by IL-1ra , indicating that also the TNFalpha induced RGS16 expression is mediated by IL-1
Lucarelli et al., Eur Cytokine Netw 2004 : Generally, Co nanoparticles had an overall pro-inflammatory effect on naive macrophages, by reducing anti-inflammatory IL-1Ra and inducing inflammatory TNF-alpha
Kaminska et al., Tumour Biol 2005 (Colorectal Neoplasms) : The levels of circulating interleukin (IL)-6, IL-8, macrophage colony stimulating factor ( M-CSF ) and interleukin 1 receptor antagonist ( IL-1ra ) significantly increased with the clinical stage of CRC, and the levels of IL-6, soluble tumor necrosis factor ( sTNF ) receptor type I ( RI ), soluble interleukin 2 receptor alpha and TNFalpha with tumor grade, while IL-6, IL-8, M-CSF, IL-1ra and sTNF RI levels significantly rose with bowel wall invasion
Millward-Sadler et al., Arthritis Res Ther 2009 (Intervertebral Disc Degeneration) : Quantitative real-time polymerase chain reaction was used to assess the effect of TNF-alpha or IL-beta stimulation on the expression of matrix metalloproteinase (MMP)-3, -9 and -13, TNF-alpha, TNF receptor 1 (TNF-R1), TNF receptor 2 (TNF-R2), IL-1alpha, IL-1beta, IL-1 receptor 1 (IL-1R1) and IL-1 receptor antagonist (IL-1Ra)
Kawano et al., Clin Exp Obstet Gynecol 2012 (MAP Kinase Signaling System) : The production of IL-8 was significantly increased by IL-1alpha or TNF-alpha , and the increase of IL-8 stimulated by IL-1alpha was suppressed by IL-1 ra in a dose dependent manner
Bigoni et al., J Orthop Res 2013 (Knee Injuries...) : Interestingly, IL-1ra levels remained always significantly lower than normally reported levels, and TNF-a levels did not increase after trauma
Zhao et al., Mol Med Report 2013 : These results indicate that the release of IL-1RA from BMSCs via paracrine mechanisms significantly blocks the production and/or activity of IL-1 and TNF-a
Seckinger et al., J Immunol 1987 (Fever) : In contrast, human recombinant tumor necrosis factor , which shares some of the biologic activities of IL-1, is not inhibited by the urinary IL-1 inhibitor
Danis et al., Clin Exp Immunol 1995 : TNF-alpha also up-regulated production of IL-1 alpha, IL-1 beta, IL-1Ra and IL-6 by monocytes, but the variability in the results of cells cultured from the same individuals on different occasions was greater
Edamitsu et al., Clin Immunol Immunopathol 1995 (Pleurisy) : The immediate permeability was inhibited by H1-antihistamine but was not affected by anti-TNF alpha , by IL-1ra , or by depletion of neutrophils ... The delayed permeability was completely inhibited by either depletion of neutrophils or by anti-TNF alpha and was not affected by IL-1ra or antihistamine
Malyak et al., J Clin Immunol 1994 : Lipopolysaccharide (LPS), granulocyte/macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) , individually, transiently increased IL-1ra steady-state mRNA levels in PMN, with associated increases in IL-1ra protein synthesis
Kutsch et al., J Invest Dermatol 1993 : Tumor necrosis factor-alpha induces interleukin-1 alpha and interleukin-1 receptor antagonist production by cultured human keratinocytes ... Only TNF-alpha induced IL-1ra and IL-1 alpha production ... The IL-1 alpha and IL-1ra response to TNF-alpha stimulation showed a varied pattern among different keratinocyte strains over 72 h of culture on plain plastic
Aiura et al., Infect Immun 1993 (Bacteremia...) : In vitro, IL-1ra inhibited S. epidermidis induced TNF from mononuclear cells by 31 % +/- 11 %, from spleen cells by 17 % +/- 4 % ( P < 0.05 ), and from whole blood by 42 % +/- 17 %
Candela et al., Mol Cell Biochem 1993 : FGF stimulated TNF alpha induced PGE2 production independent of potential TNF alpha mediated IL-1 production, as neither anti-IL-1 mAbs nor IL-1 receptor antagonist protein (IRAP) inhibited TNF alpha induced-PGE2 production or the stimulatory effect of FGF
Granowitz et al., Mol Med 1995 (HIV Seropositivity...) : These effects are blocked by IL-1Ra and partially mediated by TNF
Torcia et al., Exp Hematol 1996 (Bone Resorption...) : The bone resorbing activity of tumor necrosis factor-alpha (TNF-alpha) or lymphotoxin ( LT ), tested alone or added to MM cell supernatants, was affected not at all by IL-1ra and only minimally by sIL-1R types I and II, suggesting that little or no endogenous IL-1 was produced by the rat cells in the assay under TNF-alpha or LT stimulation
Marie et al., Cytokine 1996 : When IL-1ra production by PMN was induced by tumour necrosis factor-alpha (TNF-alpha) , IL-10 and IL-4 both amplified its release and its presence as a cell associated form ... IL-4 was active in the different combinations tested ; IL-13 and TGF-beta did not further modulate LPS- and TNF-alpha induced IL-1ra production by PMN
Ruth et al., J Immunol 1996 (Granuloma) : In vivo depletion of IL-4, IL-10, IL-12, IFN-gamma, or TNF-alpha with 5 mg of cytokine-specific neutralizing rabbit IgG revealed that IFN-gamma and TNF-alpha were required for maximal IL-1ra production by Mphi
Matsukawa et al., Lab Invest 1997 (Arthritis, Experimental...) : Maximum levels of TNF alpha and IL-8 were detected at 2 hours after LPS-injection, whereas IL-1 beta and IL-1 receptor antagonist (IL-1Ra) were detected at 6 and 9 hours, respectively ... These results provide new evidence that IL-8 as well as TNF alpha are the most proximal cytokines and induce subsequent production of IL-1 beta and IL-1Ra
Puren et al., J Clin Invest 1998 : IL-18 did not induce antiinflammatory cytokines, IL-1Ra , or IL-10, although IL-18 induction of TNFalpha was inhibited by IL-10
Pastore et al., J Allergy Clin Immunol 1998 (Dermatitis, Atopic) : In contrast, spontaneous release of IL-1alpha, IL-1ra, GM-CSF, and TNF-alpha was increased in the supernatants of unstimulated keratinocytes from patients with AD compared with keratinocytes from control subjects, with IL-1ra and GM-CSF reaching statistically significant difference
Matsukawa et al., Lab Invest 1998 (Arthritis) : These results provide evidence that IL-8 and TNFalpha were responsible for the production of IL-1beta and IL-1Ra , and that IL-1beta was responsible for the second phase of IL-1beta and IL-8 production