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CCND1 — PRDX2

Text-mined interactions from Literome

Alao et al., Molecular cancer 2006 : We have demonstrated previously, that TSA induces the ubiquitin dependent degradation of cyclin D1 in MCF-7 breast cancer cells ... Additional studies were initiated in order to further investigate the effect of TSA on cyclin D1 regulation using sub-cellular fractionation techniques
Alao et al., Molecular cancer 2006 (Breast Neoplasms) : We have previously shown that the histone deacetylase inhibitor trichostatin A (TSA) induces the rapid ubiquitin dependent degradation of cyclin D1 in MCF-7 breast cancer cells prior to repression of cyclin D1 gene (CCND1) transcription ... Here we provide further evidence for TSA induced ubiquitin dependent degradation of cyclin D1 and demonstrate that GSK3beta mediated nuclear export facilitates this activity ... We have demonstrated that rapid TSA induced cyclin D1 degradation in MCF-7 cells requires GSK3beta mediated Thr-286 phosphorylation and the ubiquitin dependent 26S proteasome pathway
Park et al., Int J Mol Med 2008 (Breast Neoplasms...) : In addition, TsA markedly down-regulated the expression of cyclin D1 and CDK4, up-regulated the expression of p21WAF1 and p53 and induced cell cycle arrest at the G1 phase in MCF10A-ras cells
Jin et al., Tissue Eng Part A 2013 : We observed that TSA increased the expression of proliferating cell nuclear antigen and cyclin D1 in hDPSCs at a certain concentration and the activation of JNK/c-Jun pathway was essential for TSA dependent hDPSC proliferation