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NFKB1 — SYT1

Text-mined interactions from Literome

Gabriel et al., Brain Res Mol Brain Res 1999 (Arterial Occlusive Diseases...) : It is proposed that the highly inducible NF-kappaB complexes resulted from induction of p65 and activation of NF-kappaB in post-ischemic reactive glia
Nakashima et al., J Am Soc Nephrol 1999 : p65 was inhibited by the three NF-kappaB inhibitors described above, whereas p50 was not
Simpson et al., J Neurochem 1999 : This study indicates that NO-releasing compounds can directly induce nuclear NF-kappaB subunit expression in rat striatum and that glucocorticoids selectively inhibit p65 subunit expression following exposure to NO
Vasiliou et al., Biochem Biophys Res Commun 2000 (Fibrosis...) : Involvement of p65 in the regulation of NF-kappaB in rat hepatic stellate cells during cirrhosis
Hajra et al., Proc Natl Acad Sci U S A 2000 (Arteriosclerosis) : In control C57BL/6 mice, expression levels of p65 , IkappaBalpha, and IkappaBbeta were 5- to 18-fold higher in the HP region, yet NF-kappaB was activated in a minority of endothelial cells
Lehmann et al., J Rheumatol 2000 : Induction of NF-kappaB DNA binding by the p65 ( RelA ) /p50 heterodimer was observed in response to incubation of Mono Mac 6 cells with SF ( 20 % in culture medium ) from 5 of 8 subjects with RA, 4 of 5 with OA, and none of 3 with undifferentiated seronegative oligoarthritis
Suk et al., J Biol Chem 2001 (Necrosis...) : IFNgamma pretreatment attenuated TNFalpha- or p65 induced NF-kappaB reporter activity, whereas it did not inhibit p65 translocation or DNA binding of NF-kappaB
Shimamura et al., Exp Cell Res 2002 (Cell Transformation, Neoplastic...) : Furthermore, expression of a dominant negative mutant of IkappaBalpha, pMEIkappaBalpha67CJ, and a dominant negative mutant of p65, p65DeltaC , resulted in decreased focus formation and NF-kappaB activity
McEvoy et al., J Immunol 2002 (Arthritis, Rheumatoid) : IL-1beta- and TNF-alpha induced NF-kappaB binding to this site is due predominantly to p65-p50 heterodimer and p50 homodimer subunit protein complexes
Wang et al., Endocrinology 2002 : The gonadotropin also induced granulosa cell p65 subunit containing NFkappaB translocation from cytoplasm to nucleus and increased NFkappaB-DNA binding activity
Lee et al., J Biol Chem 2003 : LY294002, dominant negative ( DN ) phosphatidylinositol 3-kinase (PI3K), or AKT ( DN ) inhibited NFkappaB activation, p65 transactivation , and cyclooxygenase-2 (COX-2) expression induced by lauric acid or constitutively active ( CA ) TLR4
Park et al., J Biol Chem 2004 : Fas associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA ( p65 ) subunit of NF-kappaB ... Moreover, FAF1 suppressed NF-kappaB activation induced by transducers of diverse NF-kappaB activating signals such as TNF receptor associated factor-2 and -6, MEKK1, and IkappaB kinase-beta as well as NF-kappaB p65 , one of the end point molecules in the NF-kappaB activation pathway, suggesting that NF-kappaB p65 might be a target molecule upon which FAF1 acts
Schölzke et al., Eur J Neurosci 2003 : Glutamate induced a rapid reduction of IkappaBalpha levels and nuclear translocation of the NF-kappaB subunit p65
Ganchi et al., Mol Biol Cell 1992 : Results from in vivo expression studies performed with these NF-kappa B p65 mutants revealed the following : 1 ) I kappa B/MAD-3 completely inhibits NF-kappa B p65 dependent transcriptional activation mediated through the human immunodeficiency virus type 1 kappa B enhancer in human T lymphocytes, 2 ) the binding of I kappa B/MAD-3 to NF-kappa B p65 is sufficient to retarget NF-kappa B p65 from the nucleus to the cytoplasm, 3 ) selective deletion of the functional nuclear localization signal present in the Rel homology domain of NF-kappa B p65 disrupts its ability to engage I kappa B/MAD-3, and 4 ) the unique C-terminus of NF-kappa B p65 attenuates its own nuclear localization and contains sequences that are required for I kappa B-mediated inhibition of NF-kappa B p65 DNA binding activity
Guo et al., Clin Cancer Res 2004 : Reduction of endogenous p65 by siRNA treatment significantly impaired CPT-11 mediated NF-kappaB activation, enhanced apoptosis, and reduced colony formation in soft agar
Sarkar et al., J Biol Chem 2004 (Breast Neoplasms...) : In addition, mangiferin inhibits TNF induced p65 phosphorylation as well as translocation to the nucleus and also inhibits NF-kappaB activation induced by other inflammatory agents like PMA, ceramide, and SA-LPS
Hu et al., Carcinogenesis 2004 (Cell Transformation, Neoplastic) : Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells ... Deficient activation of p65 contributes to the lack of NF-kappaB activation in transformation-resistant ( P- ) cells ... We hypothesized that the differential NF-kappaB activation involves differential p65 phosphorylation arising from enzyme activity differences
Fan et al., Endocrinology 2005 : Interestingly, activation of NF-kappaB by either forced expression of the p65 subunit or NF-kappaB inducing kinase up-regulated ArPII activity
Rodríguez-Iturbe et al., Am J Nephrol 2004 (Hypertension, Renal) : Tubulointerstitial accumulation of lymphocytes, macrophages, angiotensin II-positive cells, cells expressing the p65 DNA binding subunit of NF-kappaB and activation of NF-kappaB in the kidney were all significantly increased ( p < 0.01 ) in the prehypertensive SHR-3 wk group and augmented progressively, with the highest values in the SHR-24 wk group
Jeong et al., J Biol Chem 2005 : A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity
Lam et al., Clin Cancer Res 2005 (Lymphoma, B-Cell...) : In the presence of tamoxifen, p65-ERD reversed the toxicity of IKK inhibition and restored expression of many NF-kappaB target genes
Planavila et al., J Biol Chem 2005 (Hypertrophy) : In hypertrophied hearts of banded rats the reduction in the expression of Pdk4 was accompanied by activation of NF-kappaB and enhanced interaction between p65 and PPARbeta/delta
Iwamoto et al., Tohoku J Exp Med 2005 (Body Weight...) : Supershift assays with specific antibodies revealed that p50, but not p52, p65 , Rel B, or c-Rel, may be involved in the activation of NF-kappaB , though the component primarily responsible for the increase could not be determined
Jin et al., Cancer Res 2005 (Prostatic Neoplasms) : Treatment of DU145 cells with CD437 resulted in a rapid decrease ( > or = 3 hours ) of IkappaBalpha, which was accompanied by increased translocation of the NF-kappaB subunit p65 from the cytoplasm to the nucleus and increased NF-kappaB DNA binding activity ( > or = 4 hours ) ... The NF-kappaB inhibitor, helenalin, inhibited CD437 induced IkappaBalpha reduction and p65 nuclear translocation
Liu et al., J Biol Chem 2006 : Phosphorylation of IkappaB-beta enhances its association with p65/RelA causing an increase in NF-kappaB DNA binding activity
Takada et al., J Immunol 2006 : AKBA did not directly affect the binding of NF-kappaB to the DNA but inhibited sequentially the TNF induced activation of IkappaBalpha kinase (IKK), IkappaBalpha phosphorylation, IkappaBalpha ubiquitination, IkappaBalpha degradation, p65 phosphorylation, and p65 nuclear translocation
Eisner et al., FEBS Lett 2006 : Supershift analysis revealed that p65 and RelB ( but not p50, p52 or cRel ) were involved in the binding of NFkappaB to DNA
Dolcet et al., J Biol Chem 2006 (Endometrial Neoplasms) : These results suggest a role for p65 phosphorylation in proteasome inhibitor induced NF-kappaB activation
Wong et al., Clin Immunol 2006 : Fas ( CD95 ) ligation inhibits activation of NF-kappa B by targeting p65-Rel A in a caspase dependent manner
Li et al., Int Immunopharmacol 2006 (Lupus Erythematosus, Systemic) : The results demonstrated that DHA decreased the expression of NF-kappaB subunit p65 protein and the activation of NF-kappaB in the renal tissue of BXSB mice in vivo
Hargett et al., J Virol 2006 : Beginning at 3 to 5 h postinfection, HSV-1 induces a robust and persistent nuclear translocation of an NF-kappaB dependent ( p50/p65 heterodimer ) DNA binding activity, as measured by electrophoretic mobility shift assay
Valdés et al., Am J Physiol Cell Physiol 2007 (Calcium Signaling) : NF-kappaB activation is mediated by IkappaBalpha degradation and p65 translocation to the nucleus
Doleschall et al., Dev Comp Immunol 2007 : The cloned bovine p65 was expressed in mammalian cells, and it induced the NF-kappaB-specific luciferase reporter gene expression
Guan et al., J Virol 2008 : In this study, we demonstrate that the phosphorylation of p50 and p65 by the catalytic subunit of protein kinase A ( PKAc ) is essential for NF-kappaB DNA binding and transactivation activity
Massoumi et al., Bioessays 2007 (Carcinoma, Adenoid Cystic) : Focusing on recent data concerning the normal functions and signaling interactions of the CYLD gene product, we explain how CYLD interferes with TNF-alpha or TLR mediated signaling as well as with JNK or NF-kappaB dependent p65/50 signaling to limit inflammation
Jones et al., Journal of inflammation (London, England) 2007 : The data support a function for PKCepsilon, JAK2 and p38 MAPK in NF-kappaB activation following p65 nuclear import
Lee et al., J Biol Chem 2008 : The antibiotic promoted nuclear translocation of p65 and activation of NF-kappaB
Beck et al., EMBO J 2008 (Inflammation) : In this respect, we found that glucocorticoids counteract the recruitment of activated Mitogen- and Stress activated protein Kinase-1 ( MSK1 ) at inflammatory gene promoters resulting in the inhibition of NF-kappaB p65 transactivation and of concurrent histone H3 phosphorylation
Cichocki et al., Mol Nutr Food Res 2008 : Both stilbenes inhibited the activation of NF-kappaB by blocking the translocation of p65 to the nucleus and increasing the retention of IkappaBa in the cytosol
Pokharel et al., Evidence-based complementary and alternative medicine : eCAM 2008 : In this study, SYT selectively suppressed NF-kappaB activation, which may be essential for TARC expression in TNF-alpha/IFN-gamma treated keratinocytes ... The inhibitory effect of SYT on NF-kappaB activation and TARC production might be associated with the anti-dermatitic effects of SYT
Dasu et al., Diabetes 2008 : High glucose increased TLR expression, myeloid differentiation factor 88, interleukin-1 receptor associated kinase-1, and nuclear factor-kappaB (NF-kappaB) p65 dependent activation in THP-1 cells
Yun et al., Mol Carcinog 2009 (Colonic Neoplasms) : The immunoblot, ELISA and EMSA analysis demonstrated that the treatment of HCT116 cells with delphinidin resulted in the inhibition of ( i ) IKKalpha, ( ii ) phosphorylation and degradation of IkappaBalpha, ( iii ) phosphorylation of NF-kappaB/p65 at Ser ( 536 ), ( iv ) nuclear translocation of NF-kappaB/p65, ( v ) NF-kappaB/p65 DNA binding activity, and ( vi ) transcriptional activation of NF-kappaB
Zhao et al., Blood 2009 : In the present study, we observed that HBZ specifically suppressed NF-kappaB-driven transcription mediated by p65 ( the classical pathway ) without inhibiting the alternative NF-kappaB signaling pathway
Takeshima et al., BMC microbiology 2009 (Helicobacter Infections) : NF-kappaB activation by Helicobacter pylori requires Akt mediated phosphorylation of p65
Ma et al., Toxicol Lett 2009 (Lung Diseases) : Next, we further observed that constitutively active GSK3beta stabilized the inhibitor of NF-kappaB ( IkappaBalpha ), inhibited p65 nuclear translocation and partially blocked BLM induced NF-kappaB activation
Cerciat et al., Glia 2010 : Finally, we report that news SERMs, ospemifene and bazedoxifene, exert anti-inflammatory actions by a mechanism involving classical estrogen receptors and by the inhibition of LPS induced NFkappaB p65 transactivation
Cheng et al., Infect Immun 2009 (Inflammation) : While activation of NF-kappaB was essential for heat inactivated S. aureus induced TNF-alpha and NO, inhibiting GSK-3beta blocked heat inactivated S. aureus induced NF-kappaB p65 nuclear translocation
Koarai et al., Am J Respir Cell Mol Biol 2010 : One hundred micromoles of H ( 2 ) O ( 2 ) enhanced the translocation of nuclear factor (NF)-kappaB p65 , but not that of interferon regulatory factor-3 (IRF-3), into the nucleus and the NF-kappaB DNA binding activity after poly ( I:C ) stimulation, which effect was inhibited not by the silencing of IRF-3 but by MG132, a proteasome inhibitor, or dexamethasone
de Mejia et al., Peptides 2009 (Inflammation) : The 5 kDa peptide inhibited most potently pro-inflammatory markers including interleukin-6 production ( IC ( 50 ) =2 microM ), interleukin-1beta production ( IC ( 50 ) =13 microM ), nuclear factor-kappa B (NF-kappaB) transactivation ( IC ( 50 ) =21 microM ), cyclooxygenase-2 expression ( IC ( 50 ) =25 microM ), nitric oxide production ( IC ( 50 ) =28 microM ), inducible nitric oxide synthase expression ( IC ( 50 ) =37 microM ), prostaglandin E ( 2 ) production ( IC ( 50 ) =41 microM ), p65 nuclear translocation ( IC ( 50 ) =48 microM ) and p50 nuclear translocation ( IC ( 50 ) =77 microM )
Zhou et al., PLoS Pathog 2009 (Cryptosporidiosis) : NF-kappaB p65 dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses
Pfosser et al., Stem Cells 2010 : We conclude that NF kappaB activation by LL37 or transient p65-transfection increases functionally relevant eEPC recruitment to ischemic muscle tissue via induction of PSGL-1 and E-selectin
Rosato et al., J Biol Chem 2010 (Leukemia) : LBH-589 triggered p65/RelA activation, NF-kappaB dependent induction of Mn-SOD2, and ROS elimination
Fenner et al., PloS one 2010 : Overexpression of CALB1, CDK2 and SAG was found to stimulate transcriptional activation by NF-kappaB, while SYT1 overexpression repressed TNFalpha dependent NF-kappaB transcriptional activation in human embryonic kidney cells
Schneider et al., Oncogene 2010 : Experiments with knockout cells show that p65 and p53 are both required for enhanced NF-kappaB activity during S-phase checkpoint activation involving ataxia-telangiectasia mutated and checkpoint kinase-1
Nadiminty et al., Cancer Res 2010 (Disease Progression...) : Comparison of the relative effects of p52 and p65 (RelA) showed that p52, but not p65 , could activate the AR. Collectively, these findings, together with previous reports that the levels of NF-kappaB2/p52 are elevated in prostate cancer cells and that active NF-kappaB2/p52 promotes prostate cancer cell growth in vitro and in vivo, suggest that NF-kappaB2/p52 may play a critical role in the progression of castration-resistant prostate cancer
Zhang et al., Mol Biol Cell 2010 : PLK1 inhibits NF-kappaB transcriptional activation induced by TNF-alpha, IL-1beta, or several activators, but not by nuclear transcription factor p65
Zak et al., Leukemia 2010 (Lymphoma, Mantle-Cell) : Fenofibrate also decreased the nuclear translocation of nuclear factor (NF)-kappaB-p65 and significantly inhibited the DNA binding of NF-kappaB in a dose dependent manner
Chen et al., J Biol Chem 2010 (Colorectal Neoplasms) : rHSP90alpha induced the activities of ERK, PI3K/Akt, and NF-kappaB p65 , but only NF-kappaB activation was involved in HSP90alpha induced integrin alpha(V) expression
Gao et al., J Biol Chem 2010 (Breast Neoplasms) : In the breast cancer cell line, MDA-MB231 cells and MCF7 cells, where the endogenous AKIP1 is abundant, the PKA signal was found to be synergized with NF-kappaB activation ; PKA activating agents enhanced NF-kappaB dependent transcriptional activity and the interaction between p65 and PKAc and augmented the phosphorylation of p65 on Ser-276
Urban et al., Genes Dev 1990 : Furthermore, excess p65 could very efficiently activate the latent form of NF-kappa B composed of p50, p65, and I kappa B, presumably by binding the I kappa B, which was released from the complex due to its inherent off rate
Vandermark et al., Virology 2012 (Cell Transformation, Viral) : In contrast, activation of NF-kB by constitutive expression of p65 inhibited proliferation and immortalization
Hussain et al., PloS one 2012 (Lymphoma, Primary Effusion) : Inhibition of NFkB activity by Bay11-7085 resulted in decreased expression of p65 in the nuclear compartment as detected by EMSA assays
Sancéau et al., J Biol Chem 1995 : LPS signaling was found to involve NF kappa B activation by the p50/p65 heterodimers
Goldring et al., Biochem Biophys Res Commun 1995 : We find NF-kappa B/Rel activation ( p50-p50 and p50-p65 ) in RAW 264.7 macrophages after lipopolysaccharide treatment and binding to both NF-kappa B sites in the mouse iNOS promoter
Shu et al., Mol Cell Biol 1993 : In contrast, NF-kappa B2 inhibited functional activation of the VCAM reporter by p65
Kanno et al., Mol Cell Biol 1994 : The initial NF-kappa B binding activity seen after induction of Tax is due almost exclusively to p50/p65 heterodimers
Sun et al., Science 1993 : Association of the newly synthesized I kappa B alpha with p65 restores intracellular inhibition of NF-kappa B DNA binding activity and prolongs the survival of this labile inhibitor
Doerre et al., Proc Natl Acad Sci U S A 1993 : The c-rel protooncogene product represses NF-kappa B p65 mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus
Paal et al., Nucleic Acids Res 1997 : The co-transfection of TBP and E1A 13S stimulated NF-kappaB p65 dependent gene expression, showing the biological significance of these interactions
Horwitz et al., Immunity 1997 : These results suggest that while p50 and p65 do not regulate the maturation of pre-B cells, NF-kappaB mediates the development or survival of an early lymphocyte precursor through regulation of an extracellular factor
Visconti et al., Oncogene 1997 (Thyroid Neoplasms) : Our results indicate that activation of the NFkappaB complex by overexpression of p65 plays a critical role in the process of thyroid cell transformation
Newton et al., Eur J Biochem 1998 (Inflammation) : We, therefore, conclude that in these epithelial cells, the repressive effects of glucocorticoids are not mediated by up-regulation of I kappaB alpha, decreased p50/p65 gene expression or inhibition of NF-kappaB DNA binding
Lyss et al., J Biol Chem 1998 : The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65
Ohkawa et al., Biochim Biophys Acta 1999 : In TNF-alpha stimulated MRC-5 cells, DNA binding and competition experiments indicated that the predominant NF-kappa B binding activity detected with nuclear extract stimulated cells is mediated by the p50/p65 complex