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BCL6 — MYLIP
Text-mined interactions from Literome
Lin et al., Leukemia 2011
(Lymphoma, B-Cell) :
We identify that, on cell adhesion to FDC, FDC induces upregulation of PRDM1 expression through downregulation of
miR-9 and let-7 families and
induces downregulation of
BCL-6 through upregulation of miR-30 family in B-lymphocytes and lymphoma cells ... We further demonstrate that the miR-30 family directly controls
BCL-6 expression and
miR-9-1 and let-7a directly
control PRDM-1 expression through targeting their 3'UTR, mediating the FDC effect
Pan et al., PloS one 2012
:
Furthermore, in BRL-3A rat liver cells, we observed that overexpression of
miR-127 significantly suppressed cell growth and directly
inhibited the expression of
Bcl6 and Setd8
Nazari-Jahantigh et al., J Clin Invest 2012
(Atherosclerosis...) :
Additionally, we found that
miR-155 directly
repressed expression of
BCL6 , a transcription factor that attenuates proinflammatory NF-?B signaling
Basso et al., J Exp Med 2012
:
Similarly, the expression of additional genes relevant for the GC phenotype, including SPI1, IRF8, and MYB, appears to be sustained via
BCL6 mediated repression of
miR-155
Sandhu et al., Proc Natl Acad Sci U S A 2012
(Leukemia, Lymphoid) :
We show that
Bcl6 is indirectly
regulated by
miR-155 through Mxd1/Mad1 up-regulation
Sawant et al., Mol Immunol 2013
(Inflammation) :
Bcl6 represses and Stat3
activates miR-21 transcription through a Stat3 binding element in the promoter, indicating opposing regulation of miR-21 by the two transcription factors via the same DNA site
Guo et al., Molecules (Basel, Switzerland) 2012
(Pancreatic Neoplasms) :
Overexpression of
miR-491-5p in the pancreatic cancer cell line SW1990 effectively
inhibited both endogenous
Bcl-XL and TP53 gene expressions
Dai et al., Nan Fang Yi Ke Da Xue Xue Bao 2013
:
CONCLSUION :
Hsa-miR9 positively
regulate the expression of
BCL-6 and apoptosis of EBV ( + ) Raji cells and EBV ( - ) Ramous cells