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HBEGF — SRC
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Pierce et al., J Biol Chem 2001
:
Experiments with various chemical inhibitors and dominant inhibitory mutants demonstrate that EGFR dependent activation of the ERK cascade after alpha(2A)AR stimulation requires Gbetagamma subunits upstream and dynamin dependent endocytosis downstream of HB-EGF shedding and EGFR activation, whereas
Src kinase activity is
required both for the release of
HB-EGF and for HB-EGF mediated ERK2 phosphorylation
Shah et al., Mol Endocrinol 2004
:
Although the Tyr319 residue of the AT1-R has been proposed to be an essential regulator of EGF-R transactivation, stimulation of wild-type and mutant ( Y319F ) AT1-R expressed in COS-7 cells caused EGF-R transactivation and subsequent ERK1/2 phosphorylation through release of
HB-EGF in a
Src dependent manner
Seo et al., J Biol Chem 2007
:
The activation of
Src increased UVB induced, Gbetagamma mediated
HB-EGF secretion, but the inhibition of Src blocked that