◀ Back to HDAC3
GPS2 — HDAC3
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
GPS2
→
HDAC3
(direct_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
Complex of HDAC3-GPS2-TBL1XR1-TBL1X
Yoon et al., EMBO J 2003
-
IRef Biogrid Interaction:
HDAC3
—
GPS2
(direct interaction, pull down)
Sanyal et al., Proc Natl Acad Sci U S A 2007*
-
IRef Biogrid Interaction:
HDAC3
—
GPS2
(physical association, affinity chromatography technology)
Sanyal et al., Proc Natl Acad Sci U S A 2007*
-
IRef Biogrid Interaction:
HDAC3
—
GPS2
(physical association, affinity chromatography technology)
Bantscheff et al., Nat Biotechnol 2011
-
IRef Biogrid Interaction:
HDAC3
—
GPS2
(physical association, affinity chromatography technology)
Joshi et al., Molecular systems biology 2013
-
IRef Biogrid Interaction:
HDAC3
—
GPS2
(physical association, affinity chromatography technology)
Zhang et al., Mol Cell 2002
-
MIPS CORUM NCOR complex:
NCOR complex complex (CORO2A-GPS2-HDAC3-NCOR1-TBL1X-TBL1XR1)
Yoon et al., EMBO J 2003
-
MIPS CORUM Kaiso-NCOR complex:
Kaiso-NCOR complex complex (CORO2A-GPS2-HDAC3-KDM4A-KIF11-NCOR1-TBL1X-TBL1XR1-TRIM33-ZBTB33)
Yoon et al., Mol Cell 2003
-
MIPS CORUM SMRT complex:
SMRT complex complex (GPS2-HDAC3-NCOR2-TBL1X-TBL1XR1)
Yoon et al., EMBO J 2003
-
MIPS CORUM NCOR-HDAC3 complex:
NCOR-HDAC3 complex complex (GPS2-HDAC3-NCOR1-TBL1X-TBL1XR1)
Zhang et al., Mol Cell 2002
-
IRef Corum Interaction:
Complex of 11 proteins
(association, coimmunoprecipitation)
Yoon et al., EMBO J 2003
-
IRef Corum Interaction:
Complex of HDAC3-GPS2-TBL1X-NCOR1-TBL1XR1
(association, anti tag coimmunoprecipitation)
Zhang et al., Mol Cell 2002
-
IRef Corum Interaction:
Complex of 19 proteins
(association, mass spectrometry studies of complexes)
Yoon et al., EMBO J 2003
-
IRef Corum Interaction:
Complex of 11 proteins
(association, far western blotting)
Yoon et al., Mol Cell 2003
-
IRef Dip Interaction:
HDAC3
—
GPS2
(physical association, anti tag coimmunoprecipitation)
Sanyal et al., Proc Natl Acad Sci U S A 2007*
-
IRef Dip Interaction:
HDAC3
—
GPS2
(physical association, pull down)
Sanyal et al., Proc Natl Acad Sci U S A 2007*
-
IRef Dip Interaction:
Complex of HDAC3-GPS2-HDAC1
(anti tag coimmunoprecipitation)
Sanyal et al., Proc Natl Acad Sci U S A 2007*
-
IRef Hprd Interaction:
HDAC3
—
GPS2
(in vitro)
Zhang et al., Mol Cell 2002
-
IRef Hprd Interaction:
HDAC3
—
GPS2
(in vivo)
Zhang et al., Mol Cell 2002
-
IRef Hprd Interaction:
Complex of 26 proteins
(in vivo)
Yoon et al., EMBO J 2003
-
IRef Hprd Interaction:
Complex of 51 proteins
(in vivo)
Zhang et al., Mol Cell 2002
-
IRef Hprd Interaction:
Complex of 51 proteins
(in vivo)
Zhang et al., Mol Cell 2002
-
IRef Hprd Interaction:
Complex of 37 proteins
(in vivo)
Yoon et al., EMBO J 2003
-
IRef Intact Interaction:
Complex of 16 proteins
(association, anti tag coimmunoprecipitation)
Jäger et al., Nature 2012
-
IRef Intact Interaction:
Complex of 22 proteins
(association, anti tag coimmunoprecipitation)
Joshi et al., Molecular systems biology 2013
-
IRef Intact Interaction:
Complex of KDM1A-NCOR1-TBL1XR1-TBL1X-HDAC3-GPS2
(association, anti bait coimmunoprecipitation)
Bantscheff et al., Nat Biotechnol 2011
-
IRef Intact Interaction:
Complex of NCOR2-ZMYM3-TBL1XR1-HDAC3-GPS2-KDM1A-TBL1X-NCOR1
(association, anti bait coimmunoprecipitation)
Bantscheff et al., Nat Biotechnol 2011
Text-mined interactions from Literome
Herdick et al., J Mol Biol 2000
:
This study demonstrates that the interaction of the VDR with
NCoR results in a preferential stabilization of the
VDR in a non-agonistic conformation ( silent state ), whereas within a complex with SRC-1 VDR is in its agonistic conformation ( activated state )
Guenther et al., Mol Cell Biol 2001
:
In contrast,
SMRT does not
activate the class II
HDAC4 , with which it also interacts
Guenther et al., Genes Dev 2002
:
Histone deacetylase 3 (HDAC3) requires the nuclear receptor corepressor
SMRT for HDAC enzyme activity
Sohn et al., Mol Endocrinol 2003
:
First, corepressor
SMRT [ for silencing mediator of thyroid hormone receptor ( TR ) and retinoic acid receptor ( RAR ) ]
inhibits the interaction of coactivator
steroid receptor coactivator-1 with liganded TR/RAR
Dong et al., Oncogene 2003
:
Studies comparing NuMA-RARalpha with NuMA-RARalpha ( deltaCC ) demonstrated that the dimerization or alpha-helical coiled-coil domain of NuMA was required for homodimer formation, transcriptional repression of wild-type RARalpha, transcriptional
activation of
STAT3 , and stability of the
NuMA-RARalpha/SMRT complex
Wu et al., J Biol Chem 2003
:
NCoR enhanced DACH1 repression, and the repression of TGF-beta induced AP-1 or Smad signaling by
DACH1 required the DACH1 DS domain ...
NCoR enhanced DACH1 repression, and the repression of TGF-beta induced
AP-1 or Smad signaling by DACH1
required the DACH1 DS domain ...
NCoR enhanced DACH1 repression, and the repression of TGF-beta induced AP-1 or
Smad signaling by DACH1
required the DACH1 DS domain
Takahashi et al., Blood 2004
(Leukemia) :
In the
presence of
Flt3-ITD ,
PLZF-SMRT interaction was reduced, transcriptional repression by PLZF was inhibited, and PLZF mediated growth suppression of leukemia cells was partially blocked
Ishii et al., Mol Endocrinol 2004
(Thyroid Hormone Resistance Syndrome) :
TR and
NCoR were located on the promoter, and T3
caused NCoR dissociation and
steroid receptor coactivator-1 recruitment
Akaike et al., Mol Cell Biol 2004
:
Furthermore, association of ERK5a and PPARgamma1 disrupted the interaction of
SMRT and PPARgamma1, thereby
inducing PPARgamma activation
Zhang et al., Genes Dev 2005
:
Here we demonstrate that, in addition to protein-protein interactions with
NCoR/SMRT , the activity of
HDAC3 is
regulated by both phosphorylation and dephosphorylation
Ki et al., Mol Cell Biol 2005
:
The small interference RNA ( siRNA ) against SMRT abolished
SMRT repression of the gene induction by
C/EBPbeta or Nrf2
Zhang et al., Mol Cell Biol 2005
:
We demonstrated that
JMJD2A selectively represses the expression of the ASCL2 gene but not other imprinted genes in the same imprinted locus in HeLa cells and that this repression
required a functional
N-CoR complex and the tandem Tudor domain of JMJD2A ... We demonstrated that JMJD2A selectively represses the expression of the
ASCL2 gene but not other imprinted genes in the same imprinted locus in HeLa cells and that this repression
required a functional
N-CoR complex and the tandem Tudor domain of JMJD2A
Hoberg et al., Mol Cell Biol 2006
:
Introduction of nonphosphorylatable mutants of RelA/p65 and
SMRT proteins or the
inhibition of
IKK activity results in active repression of NF-kappaB promoters by tethering the SMRT-HDAC3 complex
Lefebvre et al., Mol Endocrinol 2006
:
Through direct phosphorylation of the corepressor silencing mediator for retinoic and thyroid hormone receptors ( SMRT ),
Akt stabilized
RAR/SMRT interaction, leading to an increased tethering of SMRT to the RARbeta2 promoter, decreased histone acetylation, down-regulation of the RARbeta2 expression, and impaired cellular differentiation in response to retinoid
Hatchell et al., Mol Cell 2006
(Breast Neoplasms) :
SLIRP is recruited to endogenous promoters ( pS2 and metallothionein ), the latter in a SRA dependent manner, while
NCoR promoter recruitment is
dependent on
SLIRP
Grégoire et al., Mol Cell Biol 2007
:
Furthermore, the nuclear receptor corepressor
SMRT ( silencing mediator of retinoid acid and thyroid hormone receptor )
stimulated the deacetylase activity of
HDAC3 towards MEF2 and PCAF
Hoshino et al., J Biochem 2007
:
Co-repressor
SMRT and class II histone deacetylases
promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression
Matsuoka et al., Biochem Pharmacol 2007
:
Disruption of
HDAC4/N-CoR complex by histone deacetylase inhibitors
leads to inhibition of
IL-2 gene expression ... We therefore focused on the
role of
HDAC4/N-CoR complex in the transcriptional regulation of
IL-2
Peterson et al., Mol Cell Biol 2007
(Breast Neoplasms) :
SMRT is
required for full expression of the ERalpha target genes cyclin D1,
BCL-2 , and progesterone receptor but not pS2, and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells ...
SMRT is
required for full expression of the ERalpha target genes
cyclin D1 , BCL-2, and progesterone receptor but not pS2, and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells ...
SMRT is
required for full expression of the
ERalpha target genes cyclin D1, BCL-2, and progesterone receptor but not pS2, and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells ...
SMRT is
required for full expression of the ERalpha target genes cyclin D1, BCL-2, and
progesterone receptor but not pS2, and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells ...
SMRT is
required for full expression of the ERalpha target genes cyclin D1, BCL-2, and progesterone receptor but not
pS2 , and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells ...
SMRT is
required for full expression of the ERalpha target genes cyclin D1,
BCL-2 , and progesterone receptor but not pS2, and its depletion significantly attenuated estrogen dependent proliferation of MCF-7 cells
Furuya et al., Mol Cell Biol 2007
(Thyroid Neoplasms) :
Since NCoR is known to modulate the actions of TRbeta mutants in vivo and in vitro, we asked whether
NCoR regulates PV-activated
PI3K signaling ... Overexpression of
NCoR in thyroid tumor cells of TRbetaPV/PV mouse
reduced PI3K signaling, as indicated by the decrease in the phosphorylation of its immediate downstream effector, p-AKT ... Conversely, lowering cellular
NCoR by siRNA knockdown in tumor cells
led to overactivated
p-AKT and increased cell proliferation and motility
Brayman et al., Mol Endocrinol 2007
(Breast Neoplasms) :
Overexpression of
PIASy did not affect P receptor B binding to the MUC1 promoter but surprisingly
led to a loss of
nuclear receptor corepressor (NCoR) , which was recruited to the promoter in response to P. Collectively, these data indicate that PIASy may be a useful target for down-regulation of MUC1 expression in various contexts
Sundaram et al., J Cell Biochem 2008
:
Co-expression of NCoR with
DACH1 significantly decreased ( 5.3-fold ) and siRNA suppression of
NCoR in DACH1 co-transfected cells
increased ( 3.6-fold ) RANKL promoter activity ... Co-expression of NCoR with DACH1 significantly decreased ( 5.3-fold ) and siRNA suppression of
NCoR in DACH1 co-transfected cells
increased ( 3.6-fold )
RANKL promoter activity
Higgins et al., Mol Endocrinol 2008
:
This study illustrates that both
SMRT and NCoR are
involved in E2-dependent repression of
VEGFR2 in MCF-7 cells ... This study illustrates that both SMRT and
NCoR are
involved in E2-dependent repression of
VEGFR2 in MCF-7 cells
Song et al., J Biol Chem 2008
:
Overexpression of SMRT and
NCoR attenuated the transcription of
beta-catenin-TCF4-specific reporter gene and of CCND1, an endogenous beta-catenin target gene ... Overexpression of SMRT and
NCoR attenuated the transcription of beta-catenin-TCF4-specific reporter gene and of
CCND1 , an endogenous beta-catenin target gene ... Overexpression of SMRT and
NCoR attenuated the transcription of
beta-catenin-TCF4-specific reporter gene and of CCND1, an endogenous beta-catenin target gene
Jennewein et al., J Immunol 2008
:
Chromatin immunoprecipitation analysis demonstrated that AC prevented the
LPS induced removal of
nuclear receptor corepressor (NCoR) from the kappaB site within the TNF-alpha promoter
Stanya et al., J Cell Biol 2008
:
Cdk2 and Pin1 negatively
regulate the transcriptional corepressor
SMRT ... Cdk2 and
Pin1 negatively
regulate the transcriptional corepressor
SMRT ...
Pin1 regulates
SMRT protein stability, thereby affecting SMRT dependent transcriptional repression ...
SMRT phosphorylation at multiple sites is
required for
Pin1 interaction, and these sites can be phosphorylated by Cdk2, which interacts with SMRT
Furuya et al., Steroids 2009
(Thyroid Neoplasms) :
Over-expression of
NCoR in thyroid tumor cells of TRbeta ( PV/PV ) mice
reduces AKT-mTOR-p70 ( S6K ) signaling ... Over-expression of
NCoR in thyroid tumor cells of TRbeta ( PV/PV ) mice
reduces AKT-mTOR-p70 ( S6K ) signaling ... Over-expression of
NCoR in thyroid tumor cells of TRbeta ( PV/PV ) mice
reduces AKT-mTOR-p70 ( S6K ) signaling ... Conversely, lowering cellular
NCoR by siRNA knockdown in tumor cells
leads to over activated
PI3K-AKT signaling to increase cell proliferation and motility ... Conversely, lowering cellular
NCoR by siRNA knockdown in tumor cells
leads to over activated
PI3K-AKT signaling to increase cell proliferation and motility
Zhang et al., J Biol Chem 2009
:
DBC1 stabilized the interaction between COUP-TFI and
NCoR by interacting directly with both proteins
Wang et al., Mol Endocrinol 2009
:
These findings demonstrate the critical
role of
NCoR/HDAC3 complex in negative regulation of
TSHalpha gene expression and show that similar complexes and overlapping epigenetic modifications can participate in both negative and positive transcriptional regulation
Karmakar et al., Mol Endocrinol 2010
(Breast Neoplasms) :
Our data link the SMRT corepressor directly with SRC family coactivators in positive regulation of ERalpha dependent gene expression and, taken with the positive correlation found for SMRT and SRC-3 in human breast tumors, suggest that
SMRT can
promote ERalpha- and SRC-3 dependent gene expression in breast cancer
Hodgson et al., Cancer Res 2011
(Neoplasm Recurrence, Local...) :
Optimal induction of
INPP4B by an androgen receptor
required the expression of the transcriptional coactivator
NCoR ... Optimal induction of INPP4B by an
androgen receptor required the expression of the transcriptional coactivator
NCoR
Portal et al., Proc Natl Acad Sci U S A 2011
(Cell Transformation, Viral) :
These data strongly support a model in which EBNA2 association with NCoR-deficient
RBPJ enhances transcription and EBNALP dismisses
NCoR and RBPJ repressive complexes from enhancers to coactivate hes1 and arglu1 but not cd21 or cd23
Zhou et al., PloS one 2012
(MAP Kinase Signaling System) :
Importantly,
miR-16 targeted the 3'-untranslated region of SMRT and
caused translational suppression of
SMRT
Finlin et al., Metab Syndr Relat Disord 2012
:
Small interfering RNA ( siRNA ) -mediated knockdown of SUMO-1 decreased PPAR?, HDAC3, and
NCoR in THP-1 cells and increased tumor necrosis factor-a (TNF-a) induction in
response to
lipopolysaccharide (LPS)
Liu et al., J Biol Chem 2012
:
SUMO1 was
required for the T3-induced recruitment of the co-activator CREB binding protein (CBP) and release of
nuclear receptor co-repressor (NCoR) on a TRE but had no significant effect on TR DNA binding
Choi et al., J Cell Physiol 2013
(Prostatic Neoplasms) :
We demonstrated that the Serine-70 of NCoR is identified the critical amino acid for
PKA dependent
NCoR phosphorylation ... More importantly, the activation of
PKA enhanced the repressive activity of
NCoR in a reporter assay and potentiated the antagonist activity in the Androgen Receptor (AR) mediated transcription
Lit et al., Anticancer Res 2013
(Breast Neoplasms...) :
At the protein level, inhibition of
LATS2 reduces the expression of cyclin-D1 and
Nuclear Receptor Co-Repressor (NCoR) while increasing the expression of p27