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MMP2 — RLN1
Text-mined interactions from Literome
Song et al., Anim Reprod Sci 2001
:
Our results showed that equine
relaxin increased the activity of total
gelatinase A ( both pro forms and mature forms ) and latent progelatinase B present in conditioned medium, latent progelatinase A present in cell extracts, and TIMP-1 and TIMP-2 present in conditioned medium
Lenhart et al., Endocrinology 2001
:
In contrast,
relaxin significantly
increased the secretion of active
matrix metalloproteinase-2 and -9 protein into uterine fluid ( P < 0.05 )
Naqvi et al., Arthritis Res Ther 2005
:
Previously, we showed that
relaxin dose-dependently
induces matrix metalloproteinase ( MMP ) expression in isolated joint fibrocartilaginous cells
Goldsmith et al., Ann N Y Acad Sci 2005
:
In addition,
relaxin negatively
regulates expression of endometrial
matrix metalloproteinases ( MMP ) , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor, tissue inhibitor of metalloproteinase 1 ... The negative
effects of
relaxin on
MMP expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix
Kamat et al., Cancer Biol Ther 2006
(Carcinoma, Endometrioid...) :
RLN stimulation
caused a significant increase in levels of activated
MMP-2 in KLE cells and activated MMP-9 in HEC-1B cells compared to unstimulated cells
Silvertown et al., Endocrinology 2006
(Lung Diseases) :
Taken together, this study provides proof-of- principle that
relaxin gene expression targeted to the mouse lungs can
result in enhanced
MMP activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation
Henneman et al., Arch Oral Biol 2008
:
Previous studies have indicated that
MMP production can be
stimulated by the hormone
relaxin
Maruo et al., Endocrine 2007
:
The
effects of rH2
relaxin on
MMP-2 , -3, -9 and TIMP-1 mRNAs levels were examined by real-time RT-PCR
Cao et al., Eur Rev Med Pharmacol Sci 2013
(Breast Neoplasms...) :
The
relaxin induced increase in
MMP-2 and MMP-9 expression was blocked when S100A4 was inhibited by S100A4 siRNA transfection