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MMP2 — SMC3

Text-mined interactions from Literome

Pinney et al., J Cardiovasc Pharmacol 2003 (Carotid Artery Injuries) : In summary, minocycline lowers MMP-2 expression, reduces SMC proliferation and migration, and inhibits neointimal hyperplasia, but its efficacy is limited by systemic toxicity
Liu et al., J Vasc Surg 2003 (Aortic Aneurysm, Abdominal) : This correlated with a decrease in MMP-2 mRNA half-life, from 49 hours to 28 hours, which suggests that doxycycline inhibits SMC MMP-2 production in part by reducing MMP-2 mRNA stability
Kothapalli et al., Acta Biomater 2010 (Aneurysm) : It was observed that SMC activation with TNF-alpha ( 10 ng ml(-1) ) induced matrix calcification and promoted production of elastolytic MMP-2 and MMP-9
Borges et al., Histopathology 2010 (Aortic Aneurysm, Thoracic) : Because the pericellular fibrinolytic system activation is able to degrade adhesive proteins, activate matrix metalloproteinase ( MMP ) , induce SMC disappearance and increase the bioavailability of TGF-ß, the aim was to investigate the plasminergic system in TAA
Jones et al., J Cell Biol 1997 : We show that a matrix metalloproteinase ( MMP ) inhibitor ( GM6001 ) suppresses SMC TN-C expression on native collagen, whereas denatured collagen promotes TN-C expression in a beta 3 integrin- dependent manner, independent of MMPs. Floating type I collagen gel also suppresses SMC MMP activity and TN-C protein synthesis and induces apoptosis, in the presence of EGF
Wang et al., J Vasc Res 1998 : Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima, and inhibition of this MMP results in reduced SMC migration and proliferation, suggesting a role for MMP-2 in neointimal development