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IL6 — PTH

Text-mined interactions from Literome

De Miguel et al., J Am Soc Nephrol 1999 : PTH ( 1-34 ) and PTHrP ( 1-34 ) rapidly induce interleukin-6 (IL-6) expression by osteoblasts
Carlstedt et al., Biosci Rep 1999 : Interleukin-6 induced suppression of bovine parathyroid hormone secretion ... The effects of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) on parathyroid hormone (PTH) secretion were investigated ... IL-6 and TNF-alpha had no acute effect on PTH secretion in extracellular Ca2+ concentrations of 0.5, 1.25 and 3.0 mM ... We conclude that PTH secretion in vitro can be suppressed by IL-6 at clinically relevant concentrations
Kim et al., J Endocrinol 1999 (Bone Resorption) : As both basal and PTH stimulated production of IL-6 and IL-11 are decreased by dexamethasone, the increased bone resorption observed in glucocorticoid induced osteopenia does not appear to be mediated by IL-6 or IL-11
Grey et al., Endocrinology 1999 (Bone Resorption) : Recently, it has been demonstrated that the cytokine interleukin-6 (IL-6) , which potently induces osteoclastogenesis, is produced by osteoblastic cells in response to PTH ... These findings demonstrate that PTH regulates systemic levels of IL-6 in experimental animals, that IL-6 is an important mediator of the bone resorbing actions of PTH in vivo and suggest that IL-6 plays a role in coupling PTH induced bone resorption and formation
Liang et al., Calcif Tissue Int 1999 : We conclude that during the immediate early phase of the anabolic response, PTH regulates c-fos, c-jun, and IL-6 expression in osteoblasts, osteocytes, megakaryocytes, and selected bone marrow hematopoietic cells in bone
Bogdanovic et al., J Cell Biochem 2000 : Parathyroid hormone inhibition of transgene activity and collagen synthesis was not affected by indomethacin or interleukin-6
Gruber et al., Biochem Biophys Res Commun 2000 (Bone Neoplasms...) : Therefore, we evaluated the effects of 1,25- ( OH ) ( 2 ) D ( 3 ), PTH , and PGE ( 2 ) on IL-6 production in stromal/osteoblastic cell lines ... While 1,25- ( OH ) ( 2 ) D ( 3 ) was marginally effective only in ST2 cells, and PTH caused a 2- to 20-fold increase in IL-6 levels MC3T3-E1 and UMR-106 cells, PGE ( 2 ) enhanced IL-6 production in the ST2 and MC3T3-E1 cell line by two to three orders of magnitude, respectively, and also induced IL-6 in fibroblastic L929 cells
Sanders et al., J Bone Miner Res 2000 : PDB pretreatment reduced IL-6 responses to 5 nM and 10 nM PTH by 61 % and 33 %, respectively, reduced IL-6 responses to 5nM and 10 nM TNF-a by 54 % and 42 %, respectively, and failed to inhibit the IL-6 responses to 0.1-10 nM IL-1beta ... The PKC inhibitor calphostin C also decreased IL-6 responses to PTH
Mitnick et al., Am J Physiol Endocrinol Metab 2001 : Parathyroid hormone induces hepatic production of bioactive interleukin-6 and its soluble receptor ... Serum levels of IL-6 and its soluble receptor (IL-6sR) are regulated in part by PTH ... The PTH/PTH related protein type 1 receptor is highly expressed in the liver, and in the current study we investigated whether the liver produces IL-6 or IL-6sR in response to PTH ... These effects were observed at near physiological concentrations of the hormone such that 1 pM PTH induced hepatic IL-6 production at a rate of approximately 0.6 ng/min
Nagy et al., J Bone Miner Res 2001 : In contrast to these findings, the stimulatory effects of PTH , TNF-alpha, and IL-1beta on the IL-6 promoter expression were enhanced by staurosporine
Radeff et al., Exp Cell Res 2001 (Bone Resorption) : Involvement of PKC-beta in PTH , TNF-alpha, and IL-1 beta effects on IL-6 promoter in osteoblastic cells and on PTH stimulated bone resorption
Li et al., Bone 2002 : Parathyroid hormone (PTH) increased RANKL and IL-6 and decreased OPG mRNA levels similarly in both wild-type and EP2-/- or EP4-/- cells
Tsingotjidou et al., Bone 2002 : Finally, we tested the effect of RGS-2 overexpression on PTH- and fluprostenol induced interleukin (IL)-6 promoter activity in MOB cells ... PTH induces IL-6 through PKA activation, whereas fluprostenol induces IL-6 through PKC activation
Chiba et al., J Vet Med Sci 2002 (Bone Resorption) : Parathyroid hormone induces interleukin-6 gene expression in bone stromal cells of young rats ... To test the hypothesis that parathyroid hormone (PTH) regulates interleukin-6 (IL-6) expression locally in bone, the expression of IL-6 mRNA was examined by in situ hybridization after a subcutaneous injection of human PTH [ 1-84 ] ( 225 microg/kg ) in 4-week old rats ... Since IL-6 is a known activator of osteoclasts, these results are consistent with the hypothesis that PTH stimulates the local IL-6 synthesis in stromal cells to indirectly activate osteoclasts
Insogna et al., J Bone Miner Res 2002 (Bone Resorption...) : Estrogen modulates parathyroid hormone (PTH) induced increases in serum IL-6/IL-6sR , such that, in the estrogen-deficient state, there is an exaggerated release of these cytokines
Radeff et al., Cell Signal 2004 (Bone Resorption) : Role of protein kinase A, phospholipase C and phospholipase D in parathyroid hormone receptor regulation of protein kinase Calpha and interleukin-6 in UMR-106 osteoblastic cells ... PTH 1-34, PTH 3-34, PTHrP and PTH 1-31 stimulated PKCalpha translocation and IL-6 promoter activity
Davies et al., J Endocrinol 2004 : The increase did not seem to be mediated through a PTH induced increase in interleukin-6 , since interleukin-6 had no effect on CFU-F numbers when substituted for PTH
Radeff et al., J Bone Miner Res 2004 : Rho and Rho kinase are involved in parathyroid hormone stimulated protein kinase C alpha translocation and IL-6 promoter activity in osteoblastic cells ... The role of small G-proteins in PTH stimulated PKC translocation and IL-6 promoter expression in UMR-106 cells was determined
Bos et al., Biochem Biophys Res Commun 1992 (Bone Resorption) : The production of interleukin 6 , induced by parathyroid hormone , in fetal rat calvarial osteoblasts was not affected by AMG
O'Brien et al., Am J Physiol Endocrinol Metab 2005 (Bone Resorption...) : IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice
Dai et al., Bone 2006 : IL-6 mRNA expression induced by PTH is rapid and transient in osteoblasts both in vitro and in vivo ... This study found that IL-6 secretion induced by PTH is also rapid and transient
Littlewood et al., Endocrinology 1991 : 1,25 ( OH ) 2D3 and PTH did not stimulate IL-6 release
Rashid et al., American journal of physiology. Renal physiology 2007 (Atherosclerosis) : PTH also significantly increased IL-6 mRNA expression without changes at protein levels ... PTH stimulates the mRNA expressions of RAGE and IL-6 and the protein expression of RAGE
Huang et al., J Biol Chem 2007 (Atherosclerosis) : Consistently, pretreatment of cells with ox-PAPC inhibited PTH induced cAMP production and expression of immediate early genes Nurr1 and IL-6
Linkhart et al., J Bone Miner Res 1991 (Bone Resorption) : PTH had no effect on IL-6 mRNA levels or IL-6 secretion
Li et al., Biochem Biophys Res Commun 1991 : Effect of parathyroid hormone on release of interleukin 1 and interleukin 6 from cultured mouse osteoblastic cells
Feroze et al., J Ren Nutr 2011 (Cachexia...) : PTH secretion is suppressed by interleukin-1 beta and interleukin-6 , which are proinflammatory cytokines that are associated with poor outcome in dialysis patients
Löwik et al., Biochem Biophys Res Commun 1989 (Bone Resorption) : Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells : a possible role of interleukin-6 in osteoclastogenesis
Feyen et al., J Bone Miner Res 1989 (Osteosarcoma) : Given that the complex process of bone remodeling is now thought to be regulated not only by systemic hormones but also by locally produced factors, the existence of a parathyroid hormone stimulated production of interleukin-6 by osteoblasts may have important physiological significance
Franchimont et al., Endocrinology 1995 : The calcium ionophore, ionomycin, enhanced IL-6 transcripts in Ob cells and the intracellular calcium chelator, 1,2-bis- ( o-aminophenoxy ) ethane-N, N,N ', N'-tetraacetic acid tetra- ( acetoxymethyl ) -ester, inhibited the induction of IL-6 transcripts by PDGF BB, PMA, and PTH
Passeri et al., Bone Miner 1994 : The anti-TNF antibody also inhibited IL-6 production in response to exogenous IL-1 or parathyroid hormone (PTH) ... In contrast, a neutralizing anti-IL-1 receptor antibody had no effect on basal, TNF- or PTH stimulated IL-6 production
Greenfield et al., J Bone Miner Res 1993 : PTH specifically increased expression of interleukin-6 ( approximately 50-fold ) and leukemia inhibitory factor ( approximately 10-fold )
Sakagami et al., J Bone Miner Res 1993 : Stimulation of interleukin-6 production by either calcitonin gene related peptide or parathyroid hormone in two phenotypically distinct bone marrow derived murine stromal cell lines ... In contrast to the specificity of the IL-6 response of the +/+ LDA11 cells to CGRP, IL-6 production by the MBA 13.2 stromal cells was stimulated by PTH whereas CGRP or CT had no effect ... These data suggest that bone marrow derived stromal cells express receptors for either CGRP or PTH in a phenotype-specific manner and that, acting via these receptors, CGRP and PTH stimulate IL-6 production by stromal cells
Greenfield et al., J Biol Chem 1996 : Stimulation by parathyroid hormone of interleukin-6 and leukemia inhibitory factor expression in osteoblasts is an immediate-early gene response induced by cAMP signal transduction ... Moreover, activation of cAMP signal transduction by parathyroid hormone and parathyroid hormone related protein is necessary and sufficient to induce both interleukin-6 and leukemia inhibitory factor
Pollock et al., J Bone Miner Res 1996 : We have previously reported that parathyroid hormone (PTH) and PTH related protein (PTHrP) stimulate expression of interleukin-6 (IL-6) and leukemia inhibitory factor (LIF) in osteoblasts in vitro
Vargas et al., J Bone Miner Res 1996 : Receptor deficiency was confirmed by determining the ability of PTH , IL-1 alpha, and TNF-alpha to stimulate IL-6 in the media of primary calvaria derived osteoblastic cell cultures from CD-1 and cytokine receptor-deficient mice ... In contrast, PTH increased IL-6 levels in the cells from all mice
Bodine et al., J Cell Biochem 1997 : Although most of these responses appeared to be unaffected by the steroid, 17 beta-E2 suppressed parathyroid hormone induced cAMP production, as well as basal interleukin-6 mRNA expression ; conversely, the steroid upregulated the steady-state expression of alkaline phosphatase message in these cells
Onyia et al., J Cell Biochem 1997 (Osteosarcoma) : We recently demonstrated that PTH induced a rapid and transient increase in interleukin-6 (IL-6) mRNA expression in rat bones in vivo ... We compared the effects of PTH on IL-6 expression with adenylate cyclase activator forskolin, PKC activator phorbol 12-myristate 13-acetate ( PMA ), calcium ionophore A23187, interleukin-1 alpha (IL-1 alpha), prostaglandin E-2 ( PGE-2 ), RS-66271 ( a parathyroid hormone related peptide analog ), and platelet derived growth factor-BB ( PDGF-BB ) ... These results demonstrate PTH , forskolin, the PTHrP analog RS-66271, and IL-1 alpha stimulate IL-6 expression by stimulating gene transcription
Liu et al., Endocrinology 1998 : One of these, MS1 cells, expressed numerous cytokines and proteins characteristic of the osteogenic lineage and showed increased production of interleukin-6 in response to PTH
Huang et al., Bone 1998 : Parathyroid hormone induces interleukin-6 heterogeneous nuclear and messenger RNA expression in murine calvarial organ cultures ... The goals of the present study were : ( 1 ) to examine PTH induction of IL-6 expression in 7-day-old mouse calvarial organ cultures ; ( 2 ) to assess the role of intracellular signaling pathways in this model ; and ( 3 ) to determine whether PTH regulates IL-6 expression by a transcriptional mechanism ... These data support the conclusion that PTH transcriptionally induces IL-6 gene expression in murine calvarial organ cultures mainly through the cAMP-PKA signaling pathway