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LEP — NOS1

Text-mined interactions from Literome

Morley et al., Peptides 1999 (Body Weight) : This study examined the effects of NPY and leptin on nitric oxide synthase (NOS) in the hypothalamus
Okuya et al., Endocrinology 2001 : Moreover, 5 nM leptin reduced the triglyceride content and suppressed inducible nitric oxide synthase mRNA expression in incubated islets
Wold et al., Hypertension 2002 (Hypertension...) : SHR myocytes displayed similar Ob-R protein abundance and basal NO levels, a blunted leptin induced increase in NOS activity as well as enhanced basal STAT3 levels compared with the WKY group
Zerani et al., J Endocrinol 2004 : Leptin increased PGF2alphaand cAMP-specific PDE, decreased basal progesterone and did not affect PGE2 and NOS levels
Mehebik et al., Am J Physiol Cell Physiol 2005 : Finally, stimulation of adipocyte NOS activity by leptin is either unaltered when protein phosphatase 2A is inhibited by 1 nM okadaic acid or completely abolished when protein phosphatase 1 (PP1) activity is inhibited by 3 nM tautomycin, which supports a crucial role for PP1 in mediating this effect of leptin ... On the whole, these experiments demonstrate that NOS activity is a novel target for leptin in adipocytes and that the leptin induced NOS activity is at least in part the result of NOS III phosphorylations via both protein kinase A and p42/p44 MAPK activation
Zerani et al., J Endocrinol 2005 : Leptin receptor expression and in vitro leptin actions on prostaglandin release and nitric oxide synthase activity in the rabbit oviduct ... In this study, we have examined the presence and the distribution of receptors for leptin ( Ob-R ) in the oviduct of rabbits, and the effects of leptin on the release of prostaglandin ( PG ) F2alpha and PGE2 and on the activity of nitric oxide ( NO ) synthase ( NOS ) by oviducts cultured in vitro ... Both leptin and NO donor inhibited PGE2 release, whereas they enhanced PGF2alpha release ; NOS inhibitor alone or with leptin increased PGE2 and decreased PGF2alpha production ; NOS activity was enhanced by leptin , while PGs did not affect this enzyme
Otero et al., Arthritis Res Ther 2005 : Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes : synergistic effect of leptin with interleukin-1 ... The objective of the present study was to investigate the effect of leptin , alone or in combination with IL-1, on nitric oxide synthase (NOS) type II activity in vitro in human primary chondrocytes, in the mouse chondrogenic ATDC5 cell line, and in mature and hypertrophic ATDC5 differentiated chondrocytes
Procopio et al., Endocrinology 2009 : Leptin stimulated endothelial nitric-oxide synthase via an adenosine 5'-monophosphate activated protein kinase/Akt signaling pathway is attenuated by interaction with C-reactive protein
Mehebik-Mojaat et al., J Cell Biochem 2009 (Insulin Resistance) : We examined insulin and leptin induced nitric oxide synthase (NOS) activity, protein amount and NOS III phosphorylation at Ser ( 1179 ) in isolated epididymal adipocytes from rat, in the presence or not of inhibitors of kinases implicated in insulin or leptin signaling pathways
Donato et al., Endocrinology 2010 : Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons