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PTMA — TP53
Text-mined interactions from Literome
Kobayashi et al., Cancer Res 2006
:
Here, we show that inappropriate activity of
prothymosin alpha (PTMA) , an oncoprotein overexpressed in human cancers,
triggers a
p53 response ...
PTMA , known to interact with HATs,
led to increased levels of acetylated
p53 ...
PTMA did not
increase the transcriptional activity of an acetylation-deficient
p53 mutant, suggesting that p53 acetylation is an indispensable part of the p53 response to PTMA ... Chromatin immunoprecipitation assays showed that excess
PTMA associates with the p21 promoter and
results in increased levels of acetylated
p53 at the p21 promoter
Zakharova et al., Mol Biol (Mosk) 2008
:
Ectopic expression of
prothymosin alpha enhanced not only p53 dependent transcription, but also intracellular level of
p53 in HeLa ( but not HCT116 ) cells