Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
PPARG
→
ESR1
(decreases, ESR1 Activity, PPARG Activity)
Evidence: ER expression alters the transcriptional regulation of PPARG - targeted gene expression and reduces both basal and stimulated PPARG-mediated reporter activity, suggesting a cross-talk between PPARG andERsignaling in breast cancer cells (89). Activation of PPARG by PGJ2 results in a significant inhibition of ErbB-2 and ErbB-3 tyrosine phosphorylation caused by neuregulin 1 (NRG1) and neuregulin 2 (NRG2) in MCF-7 cells (90)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *