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PTGS2 — SHBG

Text-mined interactions from Literome

Vanecková et al., Physiol Res 2005 (Body Weight...) : The present study was performed to evaluate the effects of sodium intake and of chronic cyclooxygenase-2 (COX-2) inhibition on systolic blood pressure (SBP) in heterozygous male transgenic rats harboring the mouse Ren-2 renin gene ( TGR ) and in transgene negative normotensive Hannover Sprague-Dawley ( HanSD )
Chen et al., Chem Res Toxicol 2012 (MAP Kinase Signaling System...) : This 2-ABP induced COX-2 expression was attenuated by ROS scavenger NAC and NADPH oxidase inhibitors apocynin and DPI ... Knocking down p22phox by siRNA significantly reduced 2-ABP induced COX-2 expression ... Blocking the ERK/JNK-AP1 signaling pathways by pharmacological inhibitors attenuated 2-ABP induced COX-2 expression ... Overexpression of the upstream ERK activator MEK1 significantly and consistently increased 2-ABP mediated COX-2 expression ... Transfection of a dominant negative c-Jun mutant, TAM-67, blocked 2-ABP mediated COX-2 expression, demonstrating that c-Jun was responsible for the transcriptional activation ... Taken together, these results demonstrate that 2-ABP induces the carcinogenic factor COX-2 and that this induction is mediated through NADPH oxidase derived ROS dependent JNK/ERK-AP-1 pathways