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EIF4E — EPHB2

Text-mined interactions from Literome

Rao et al., J Biol Chem 1999 : In contrast, inhibition of ERK2 activity by PD 098059 led to a significant loss of PGF2alpha induced eIF4E and 4E-BP1 phosphorylation, global protein synthesis, and bFGF-2 expression ... These findings demonstrate that 1 ) PI3-kinase dependent and independent mechanisms appear to be involved in PGF2alpha induced activation of ERK2 ; 2 ) PGF2alpha induced eIF4E and 4E-BP1 phosphorylation appear to be mediated by both ERK dependent and PI3-kinase dependent rapamycin-sensitive mechanisms ; and 3 ) ERK dependent eIF4E phosphorylation but not PI3-kinase dependent p70 ( S6k ) activation correlates with PGF2alpha induced global protein synthesis and bFGF-2 expression in VSMC
Davies et al., J Biol Chem 2004 (MAP Kinase Signaling System) : In addition, CD40 ligation was found to mediate a PI3K- and mammalian target of rapamycin (mTOR) dependent phosphorylation of 4E-BP1 and its subsequent dissociation from the mRNA cap binding protein eIF4E as well as an ERK dependent phosphorylation of eIF4E , thus promoting translation initiation
Ishida et al., Circ Res 2003 : PD98059 or introduction of kinase-inactive MEK1/MKK1, but not SB202190 or kinase-inactive p38 MAP kinase, inhibited Ang II-induced Mnk1 activation and eIF4E phosphorylation, suggesting that ERK , but not p38 MAP kinase, is required for Ang II-induced Mnk1-eIF4E activation
Banko et al., J Neurochem 2004 : NMDA receptor activation results in PKA- and ERK dependent Mnk1 activation and increased eIF4E phosphorylation in hippocampal area CA1 ... The NMDA induced activation of Mnk1 and increased phosphorylation of eIF4E were dependent on PKA and ERK , but not PKC, and were present in synaptoneurosome preparations
Mariappan et al., J Biol Chem 2005 : VEGF induced phosphorylation of Mnk1 and eIF4E required phosphorylation of PLCgamma, c-Src, and Erk ... VEGF also stimulates Erk dependent phosphorylation of Mnk1 and eIF4E , crucial events in the initiation phase of protein translation
Argadine et al., Am J Physiol Cell Physiol 2011 : In contrast, ERK & frac12 ; phosphorylation and its downstream effector eIF4E increased 1.7-fold at DNV-1D and phosphorylated GSK3ß increased 1.5-fold at DNV-3D ( P < 0.05 for both comparisons )
Melemedjian et al., Molecular pain 2011 (Disease Models, Animal...) : Peripheral nerve injury induced reorganization of translation machinery in the peripheral nervous system of rats and mice, including enhanced mTOR and ERK activity, increased phosphorylation of mTOR and ERK downstream targets, augmented eIF4F complex formation and enhanced nascent protein synthesis