Khatiwala et al., J Bone Miner Res 2009
(MAP Kinase Signaling System) :
Inhibition of RhoA , ROCK, or the MAPK pathway diminished RUNX2 activity and delayed the onset of osteogenesis as shown by altered osteocalcin ( OCN ) and bone sialoprotein ( BSP ) gene expression, alkaline phosphatase (ALP) activity, and matrix mineralization
Tang et al., Int J Biochem Cell Biol 2012
:
RhoA-V14 , a constitutively active form of RhoA, could activate the MEK/ERK/Runx2 signaling