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PF4 — VEGFA

Text-mined interactions from Literome

Yang et al., BMC cancer 2011 (Disease Models, Animal...) : PF4 and p17-70 significantly attenuated VEGF production, both in vitro and in vivo
Gengrinovitch et al., J Biol Chem 1995 : Platelet factor-4 inhibits the mitogenic activity of VEGF121 and VEGF165 using several concurrent mechanisms ... The binding of 125I-VEGF165 to the VEGF receptors of endothelial cells, and the heparin dependent binding of 125I-VEGF165 to a soluble extracellular domain of the VEGF receptor KDR/flk-1, were inhibited by the angiogenesis inhibitor platelet factor-4 (PF4) ... These results indicate that PF4 may inhibit VEGF165 binding to VEGF receptors by disrupting the interaction of VEGF165 with cell surface heparan sulfates