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TXN — VEGFA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: VEGFA → TXN (increases, VEGFA Activity) Welsh et al., Cancer Res 2002*
  Evidence: Trx-1 transfection also caused a significant increase in the protein products of hypoxia-responsive genes, including vascular endothelial growth factor (VEGF) and nitric oxide synthase 2 in a number of different cell lines (MCF-7 human breast and HT29 human colon carcinomas and WEHI7.2 mouse lymphoma cells) under both normoxic and hypoxic conditions.

Text-mined interactions from Literome

Nagashima et al., Clin Exp Immunol 1999 (Arthritis, Rheumatoid...) : In contrast, MTX and SASP did not affect VEGF production
Welsh et al., Cancer Res 2002 (Breast Neoplasms...) : The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression : Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis
Welsh et al., Mol Cancer Ther 2003 (Breast Neoplasms...) : The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia induced factor 1alpha and vascular endothelial growth factor formation
Kim et al., Int J Oncol 2005 (Neoplasms...) : Overexpression of Trx also caused a significant increase of VEGF in protein and RNA levels under normoxic and hypoxic conditions
Tipple et al., Am J Respir Cell Mol Biol 2009 (Bronchopulmonary Dysplasia...) : Alterations in vascular endothelial growth factor ( VEGF ) contribute to alveolar simplification seen in animal models of bronchopulmonary dysplasia, and VEGF expression is redox regulated by thioredoxin (Trx)-1 in other diseases