◀ Back to MAPK8
MAPK8 — MCL1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MCL1
→
MAPK8
(increases, MCL1 Activity)
Evidence: We found that JNK phosphorylated Ser-121 and Thr-163 of Mcl-1 in response to stimulation with H(2)O(2) and that transfection of unphosphorylatable Mcl-1 resulted in an enhanced anti-apoptotic activity in response to stimulation with H(2)O(2).
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Leuenroth et al., Surgery 2000
:
Western blot analysis confirmed that the inhibition of p38
MAPK led to a significant decrease in
Mcl-1 expression
Chetoui et al., Mol Cancer Res 2008
(Melanoma) :
Our results further show that the expression of
Mcl-1 in melanoma cells is
regulated by the
mitogen activated protein kinase/extracellular signal regulated kinase ( ERK ) and not by phosphatidylinositol 3-kinase/AKT signaling pathway
Dyugovskaya et al., Journal of translational medicine 2012
(Anoxia...) :
Specifically, the balance between pro-apoptotic Bax and anti-apoptotic Mcl-1 protein expression, and the potential
involvement of
p38MAPK and ERK1/2 signaling pathways in the control of
Mcl-1 expression were investigated ... Accordingly, both ERK and
p38MAPK inhibitors
attenuated the IH-induced
Mcl-1 increase