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RAC1 — RASGRF2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of RAC1 activity: RAC1/GDP complex (RAC1) → RASGRF2 (RASGRF2) (modification, collaborate) Kesavapany et al., J Neurosci 2004*, Fan et al., Curr Biol 1998*
  Evidence: assay, physical interaction
• Reactome Reaction: RASGRF2 → RAC1 (reaction) Harrington et al., J Neurosci 2002

Text-mined interactions from Literome

Kiyono et al., J Biol Chem 2000 : Tyrosine phosphorylation of Ras-GRF1 is critical for the induction of Rac-GEF activity as evidenced by inhibition by tyrosine kinase inhibitors ... Herein, we show that the nonreceptor tyrosine kinase Src phosphorylates Ras-GRF1 , thereby inducing Rac-GEF activity
Yang et al., Mol Biol Cell 2006 : These results suggest that coordinated activation of H-Ras and Rac1 by Ras-GRF1 may be a significant controller of neuronal cell size