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CXCL12 — IL10

Text-mined interactions from Literome

Nanki et al., J Immunol 2000 : In addition, SDF-1alpha costimulated proliferation of CD4+ T cells and production of IL-2, IFN-gamma, IL-4, and IL-10
Damås et al., Circulation 2002 (Angina, Unstable) : In vitro, SDF-1alpha ( 500 ng/mL ) reduced both unstimulated and endotoxin/mitogen stimulated mRNA and protein levels of monocyte chemoattractant protein-1, interleukin-8 , matrix metalloproteinase-9, and tissue factor while increasing tissue inhibitor of metalloproteinases-1 in PBMC from patients with unstable angina
Wright et al., Microbes Infect 2004 : IL-10 and IL-13 reduced S. aureus induced osteoblast C-X-C chemokine secretion, whereas IL-4 decreased CXCL8 secretion 2.5-fold and increased CXCL10 secretion 3-fold ( all P < 0.05 )
Kremer et al., J Immunol 2007 : Together, these results delineate the molecular mechanisms responsible for SDF-1 costimulation of T cell IL-10 secretion
Rossato et al., Eur J Immunol 2007 : We also show that IL-10 induced transcriptional repression of TNF-alpha and CXCL8 genes consists of two distinct phases : an early one, occurring rapidly and in a protein synthesis independent manner, followed by a second phase, more delayed and dependent on protein synthesis
Tamassia et al., Int Immunol 2008 (Sepsis...) : Consistent with the presence of a fully functional IL-10R, modulation of LPS induced CXCL8 , CCL4, tumour necrosis factor-alpha and IL-1ra gene expression was also rapidly induced by IL-10 in septic, but not normal, neutrophils