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EGF — SPP1
Text-mined interactions from Literome
Zhang et al., Zhonghua Yi Xue Za Zhi 2003
(Liver Neoplasms) :
To investigate the
effect of
epidermal growth factor (EGF) on the expression of
osteopontin (OPN) in liver cancer HepG2 cells ... Pretreatment of Wortmannin significantly reduced the
EGF induced
OPN expression ...
EGF increases the
OPN expression, possibly through PI3 signaling pathway
Zhang et al., World J Gastroenterol 2004
(Carcinoma, Hepatocellular...) :
Enhancement of
osteopontin expression in HepG2 cells by
epidermal growth factor via phosphatidylinositol 3-kinase signaling pathway ... The aim of this study was to investigate the
effect of
epidermal growth factor on the expression of
osteopontin in HepG2 cells, and to explore the signal transduction pathway mediated this expression ... Application of wortmannin caused a dramatic reduction of
epidermal growth factor induced
osteopontin expression
Barak-Shalom et al., Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1995
:
The phorbol ester TPA -- an activator of protein kinase C -- and to a lesser extent FGF but not
EGF ,
stimulated osteopontin gene expression ... Parathyroid hormone caused a dose dependent attenuation of osteopontin phosphorylation and inhibited the
EGF dependent
osteopontin phosphorylation
Chackalaparampil et al., Oncogene 1996
(Osteopetrosis) :
Results obtained from studies using inhibitors of receptor tyrosine kinases ( RTKs ) and protein kinase C ( PKC ) suggest that PKC and RTK are positioned in a pathway with PKC as the downstream effector for the EGF induced OPN gene expression in SRC-/- cells, and that pp60c-src and
EGF may
regulate OPN gene expression through a common signalling pathway
Malyankar et al., Kidney Int 1997
:
mRNA stability and nuclear run on assays suggest that
induction of
osteopontin expression by TGF beta 1 and
EGF is via increased transcription of the osteopontin gene