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E2F1 — IGF2
Text-mined interactions from Literome
Zheng et al., Cancer Res 2009
(Prostatic Neoplasms) :
E2F1 up-regulated the production of EGR1 induced growth factors, epidermal growth factor, platelet derived growth factor, and
insulin-like growth factor II , which in turn activated the phosphoinositide-3-kinase/Akt pathway to resist drug induced apoptosis
Schayek et al., Growth Horm IGF Res 2010
(Prostatic Neoplasms) :
The aim of this study was to investigate the
involvement of
E2F1 in regulation of
IGF-IR gene transcription ... Furthermore, deletion and bioinformatic analyses indicate that the ability of
E2F1 to
stimulate IGF-IR promoter activity was correlated with the number of E2F1 sites in the promoter region ... In summary, we provide evidence that
E2F1 regulates
IGF-IR gene transcription in prostate cancer cells via a mechanism that involves direct binding to specific elements in the proximal IGF-IR promoter