Gene interactions and pathways from curated databases and text-mining

◀ Back to CASP3

CASP3 — MAP3K1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Gebauer et al., Int J Oncol 2000 (Adenocarcinoma...) : Analysis of the defective apoptotic pathway in 2008/C13 cells indicates that these cells are deficient in the proteolytic activation of MEKK1 by caspase-3
Villunger et al., J Immunol 2000 : It has been reported that cross linking Abs to Fas trigger c-Jun N-terminal kinase (JNK) signaling via caspase mediated activation of MEKK1 ( JNK kinase kinase ), elevation of ceramide levels or by recruitment of death domain associated protein ( DAXX ) to Fas
McGuire et al., J Biol Chem 2001 (Carcinoma, Squamous Cell) : Selective induction of caspase dependent MEK cleavage and up-regulation of MEKK-1
Schlesinger et al., J Biol Chem 2002 : Here, we show that caspase dependent cleavage of MEKK1 relocalizes the protease generated 91-kDa kinase fragment from a particulate fraction to a soluble cytoplasmic fraction
Bild et al., Oncogene 2002 : The mechanism for MEKK1 induced apoptosis involves caspase mediated cleavage of MEKK1 , releasing a pro-apoptotic 91 kDa kinase fragment that serves to further amplify caspase activation in a feedback loop ... MEKK1 induced apoptosis is amplified by blocking PI-3 kinase activation and overexpression of AKT blocked both MEKK1 induced apoptosis and caspase activation
Johnson et al., Cancer Metastasis Rev 2002 (Prostatic Neoplasms) : Calcitriol induces PARP cleavage, increases the bax/bcl-2 ratio, reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs, P-Erk-1/2 ) and phosphorylated Akt ( P-Akt ), induces caspase dependent MEK cleavage and up-regulation of MEKK-1 , all potential markers of the apoptotic pathway
Oida et al., Mol Cancer Ther 2007 (Lung Neoplasms) : Molecular analysis of Ad-mda7 treated H1299-dnI kappa B alpha tumors showed increased MEKK1 cleavage and activation of caspase-3 compared with Ad-mda7 treated H1299-Neo tumors
Widmann et al., Mol Cell Biol 1998 : Following activation by genotoxins, MEKK1 was cleaved in a caspase dependent manner into an active 91-kDa kinase fragment ... Expression of MEKK1 stimulated DEVD directed caspase activity and induced apoptosis
Deak et al., Proc Natl Acad Sci U S A 1998 : Activation of both SAPK and MEKK1 after Fas ligation is prevented by both viral and chemical caspase 3 inhibitors, which in contrast fail to block activation of SAPK by rapidly acting cell stresses