◀ Back to POLDIP2
MMP1 — POLDIP2
Text-mined interactions from Literome
Westermarck et al., Cancer Res 2000
(Carcinoma, Squamous Cell...) :
Activation of
fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is
mediated by
p38 mitogen activated protein kinase and c-Jun NH2-terminal kinase-2 ... The induction of
MMP-1 expression correlates with activation of c-Jun NH2-terminal kinase (JNK) and p38 mitogen activated protein kinase and phosphorylation of c-Jun and activating transcription factor-2 ( ATF-2 ) and is
dependent on the activity of
p38 mitogen activated protein kinase
Fan et al., Rheumatol Int 2006
:
Our data suggest that ERK and NFkB pathways are particularly important for IL-1beta regulating collagen type II and MMP-1 and -13 expression and that
p38 , but not JNK is additionally
involved in
MMP-1 and -13 induction
Kunisch et al., Ann Rheum Dis 2007
(Arthritis, Rheumatoid...) :
Strikingly, RA-SFB are insensitive to
p38 inhibition of
MMP-1 secretion
Junttila et al., Oncogene 2007
(Carcinoma, Squamous Cell...) :
Inhibition of endogenous
p38alpha or p38delta activity by adenoviral delivery of corresponding dominant negative p38 isoforms potently
reduced MMP-13 and
MMP-1 expressions, and suppressed the invasion of HNSCC cells through collagen
Papazoglou et al., Br J Dermatol 2011
:
Our studies in HDFs demonstrated that both a Syk inhibitor and Syk siRNA were able to
inhibit MMP-1 expression in HDFs exposed to UV and that overexpression of Syk increased MMP-1 expression and the activity of JNK kinase, but not
p38 or Erk1/2 MAP kinase
Lim et al., FEBS Lett 1998
(Carcinoma, Non-Small-Cell Lung...) :
That
p38 activity was
required for EMMPRIN stimulation of
MMP-1 was evident from results showing that the p38 inhibitor SB203580 blocked this response