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FGF2 — SDC4

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FGF2 → SDC4 (increases)
  Evidence: Two types of receptors have been identified for FGF-2: high affinity tyrosine-kinase FGF receptors (FGFRs) (123) and low affinity heparan sulfate proteoglycans (HSPGs). Thus far, at least four members of FGFRs have been identified. They represent low number (approx. 10,000 per cell), but high affinity sites (Kd of 20-600 pM). Low affinity binding sites (Kd of 2-20 nM) with high capacity (approx. 1 million sites per cell) were identified as proteoglycans, including syndecan and perlecan, containi...
• NCI Pathway Database Syndecan-4-mediated signaling events: Syndecan-4 (SDC4) → Syndecan-4/FGFR1/FGF complex (SDC4-FGFR1_FGFR1-FGF2) (modification, collaborate)
  Steinfeld et al., J Cell Biol 1996*, Kojima et al., J Biol Chem 1996*
  Evidence: physical interaction
• NCI Pathway Database Syndecan-4-mediated signaling events: Syndecan-4 (SDC4) → FGF2 (FGF2) (modification, collaborate) Steinfeld et al., J Cell Biol 1996*, Kojima et al., J Biol Chem 1996*
  Evidence: physical interaction
• NCI Pathway Database Syndecan-4-mediated signaling events: Syndecan-4/FGFR1/FGF complex (SDC4-FGFR1_FGFR1-FGF2) → P11362 (FGFR1/FGFR1) (modification, collaborate) Steinfeld et al., J Cell Biol 1996*, Kojima et al., J Biol Chem 1996*
  Evidence: physical interaction
• NCI Pathway Database Syndecan-4-mediated signaling events: Syndecan-4/FGFR1/FGF complex (SDC4-FGFR1_FGFR1-FGF2) → FGF2 (FGF2) (modification, collaborate) Steinfeld et al., J Cell Biol 1996*, Kojima et al., J Biol Chem 1996*
  Evidence: physical interaction
• Reactome Reaction: FGF2 → SDC4 (direct_complex) Steinfeld et al., J Cell Biol 1996*
• Reactome Reaction: FGF2 → SDC4 (reaction) Steinfeld et al., J Cell Biol 1996*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SDC4 — FGF2 (association, biochemical) Ma et al., J Cell Biol 2006*
• IRef Matrixdb Interaction: SDC4 — FGF2 (direct interaction, enzyme linked immunosorbent assay) Parsi et al., Matrix Biol 2010*

Text-mined interactions from Literome

Bodo et al., Eur J Cell Biol 1999 (Craniofacial Dysostosis) : A regulatory role of fibroblast growth factor in the expression of decorin, biglycan, betaglycan and syndecan in osteoblasts from patients with Crouzon 's syndrome
Volk et al., J Biol Chem 1999 : Mutations of heparan sulfate attachment sites on S4 construct abolished syndecan-4 dependent augmentation of bFGF responses
Iwabuchi et al., Mech Dev 2006 : Syndecan-4 dependent FGF stimulation of mouse vibrissae growth
Velleman et al., Poult Sci 2007 : This result indicates that FGF2 responsiveness was not affected by the overexpression of syndecan-1, syndecan-4 , and glypican-1 during differentiation
Shimabukuro et al., Matrix Biol 2008 : Moreover, dot blot analysis showed that FGF-2 did not alter the level of syndecan-1 and -2, but enhanced the level of syndecan-4 in culture supernatants of FGF-2 stimulated HPDL cells
Velleman et al., Poult Sci 2008 : The effect of fibroblast growth factor 2 on the in vitro expression of syndecan-4 and glypican-1 in turkey satellite cells ... In the present study, the effect of FGF2 on the expression of syndecan-4 and glypican-1 was measured by real-time PCR during turkey myogenic satellite cell proliferation and differentiation in vitro ... These results suggest that FGF2 growth factor signaling is, in part, regulated by an autoregulatory loop involving FGF2 regulation of syndecan-4 and glypican-1 expression and will affect the growth of skeletal muscle by modulating the proliferation and differentiation of satellite cells
Bansal et al., Mol Cell Neurosci 1996 : The levels of mRNA expression were regulated by FGF-2 : in late progenitors, FGF-2 induced a doubling of the mRNA levels of syndecan-2, -3, and -4, while those for syndecan-1 and glypican remained unaffected ; in mature OLs, the levels of syndecan-1 mRNA were up-regulated, the levels of syndecan-2 and -4 and glypican were down-regulated
Horowitz et al., J Biol Chem 1998 : Because treatment with the phosphatase inhibitor calyculin prevented the bFGF induced decrease in syndecan-4 phosphorylation, the effect of bFGF appears to be mediated by a protein serine/threonine phosphatase type 1 or 2A