◀ Back to FGF2

FGF2 — SLPI

Text-mined interactions from Literome

Weiss et al., J Cell Physiol 2010 (Hypertrophy) : bFGF or parathyroid hormone-like peptide (PTHrP) inhibited the TGF-beta-responsive COL2A1 and COL10A1 expression and ALP induction when added from day 0 or 21
Kim et al., J Endod 2010 : ALP activity, the mineralization, and mRNA expression for odontoblastic markers were enhanced by FGF-2 in HDPCs. FGF-2 also up-regulated the expression of IL-6, IL-8, MCP-1, MIP-1a, and MIP-3a mRNAs, which were attenuated by inhibitors of p38, ERK1/2 and p38 MAP kinases, protein kinase C, phosphoinositide-3 kinase, and NF-?B
Chen et al., Int J Mol Med 2011 : We found that bFGF could increase the mRNA expression levels of osteoblast differentiation factor and the activity of alkaline phosphatase (ALP)
Kasperk et al., Growth Factors 1990 : While basic fibroblast GF ( FGF ), transforming GF beta-1 ( TGF beta ), and platelet derived GF ( PDGF ) enhance DNA synthesis, they had the opposite effect on alkaline phosphatase (ALP) activity in cell extracts : FGF , TGF beta, and PDGF inhibited cell ALP but strongly stimulated DNA synthesis
Wu et al., J Endod 2012 : In contrast, bFGF reduced the ALP activity, mineral nodule formation, and the expression of ALP, osteocalcin, bone sialoprotein, and dentin sialophosphoprotein
Kinehara et al., PloS one 2013 : We found that in the presence of FGF-2 , an inhibitor of protein kinase C ( PKC ), GF109203X ( GFX ), increased ALP activity
el Hafny et al., J Cell Physiol 1996 : The effects of bFGF , astroglial factors, and retinoic acid ( a cell differentiation agent ) on GTP and ALP activities were separately or simultaneously studied in order to define optimal culture conditions for induction of these two specific enzymes of the blood-brain barrier
Duvos et al., In Vitro Cell Dev Biol Anim 1997 (Bone Resorption) : bFGF reduced ALP activity slightly without an effect on calcium metabolism