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INS — RAC1
Text-mined interactions from Literome
Dadke et al., J Biol Chem 2003
:
Rat fibroblasts lacking PTP1B expression do not activate Src or
Rac in
response to
insulin and can not reorganize actin
Amin et al., Endocrinology 2003
:
Further, stable expression of a dominant negative ( N17Rac ) form of
Rac into INS-1 cells
resulted in a significant reduction in mastoparan stimulated
insulin secretion from these cells
Kowluru et al., Endocr Res 2003
:
These data suggest that activation of preexisting intramitochondrial
Rac1 and Cdc42 may be
sufficient to regulate SAME induced
insulin secretion
Li et al., Am J Physiol Endocrinol Metab 2004
(Second Messenger Systems) :
Expression of a dominant negative
Rac1 mutant ( N17Rac1 ) abolished glucose induced translocation of Rac1 and significantly
inhibited insulin secretion stimulated by glucose and forskolin ... However,
N17Rac1 expression did not significantly
affect insulin secretion induced by high K+ ... Expression of wild-type
Rac1 or a constitutively active Rac1 mutant ( V12Rac1 ) did not significantly
affect either the stimulated
insulin secretion or basal release, suggesting that Rac1 activation is essential, but not sufficient, for evoking secretory process ... These data suggest, for the first time, that
Rac1 may be
involved in glucose- and forskolin stimulated
insulin secretion, possibly at the level of recruitment of secretory granules through actin cytoskeletal network reorganization
JeBailey et al., Diabetes 2007
(Insulin Resistance) :
Ceramide- and oxidant induced insulin resistance involve loss of
insulin dependent
Rac-activation and actin remodeling in muscle cells ... Here, we show that
insulin dependent
Rac activation and its consequent actin remodeling were abolished upon exposure of L6 myotubes beginning at doses of C2-ceramide or oxidant producing glucose oxidase as low as 12.5 micromol/l and 12.5 mU/ml, respectively
Wang et al., J Biol Chem 2007
(Insulinoma) :
Importantly, Rac1 activation and function was linked in a common pathway downstream of Cdc42 ; Cdc42 depletion ablated glucose induced Rac1 activation, and expression of constitutively active
Rac1 in Cdc42 depleted cells functionally
restored glucose stimulated
insulin secretion
Gündüz et al., Arterioscler Thromb Vasc Biol 2010
:
Insulin stimulated the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and NO production, and it
activated Rac1
Chiu et al., Cell Signal 2011
(Insulin Resistance) :
This review summarises the current thinking on the
regulation of
Rac1 by
insulin , the role of Rac dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle
Nozaki et al., Cell Signal 2013
:
Insulin induced
Rac1 activation, on the other hand, was completely inhibited by this inhibitor ... Finally,
insulin induced
Rac1 activation was indeed inhibited by Akt2 knockdown ... Together, these results reveal a novel regulatory mechanism involving Akt2 for
insulin dependent
Rac1 activation
Kohn et al., EMBO J 1995
:
Insulin stimulates the kinase activity of
RAC-PK , a pleckstrin homology domain containing ser/thr kinase