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ADCYAP1 — INS

Text-mined interactions from Literome

Filipsson et al., Biochem Biophys Res Commun 1999 : We examined whether endogenous PACAP within the islets might contribute to glucose stimulated insulin secretion by immunoneutralizing endogenous PACAP
Jamen et al., J Clin Invest 2000 (Glucose Intolerance) : In vitro, in the isolated perfused pancreas, the insulin secretory response to PACAP was reduced by 50 % in PAC1 ( -/- ) mice, whereas the response to VIP was unaffected
Filipsson et al., Am J Physiol Regul Integr Comp Physiol 2000 : PACAP contributes to insulin secretion after gastric glucose gavage in mice ... We hypothesized that this contribution involves PACAP and show here that the PACAP receptor antagonist PACAP- ( 6 -- -27 ) ( 1.5 nmol/kg iv ) reduces the 15-min insulin response to gastric glucose ( 150 mg/mouse ) by 18 % in anesthetized mice ( P = 0.041 ) ... The PACAP antagonism was specific because intravenous PACAP- ( 6 -- -27 ) inhibited the insulin response to intravenous PACAP-27 plus glucose without affecting the insulin response to intravenous glucose alone ( 1 g/kg ) or glucose together with other insulin secretagogues of potential incretin relevance of intestinal ( GLP-1, gastric inhibitory polypeptide, cholecystokinin ) and neural ( vasoactive intestinal peptide, gastrin releasing peptide, cholinergic agonism ) origin ... We conclude that PACAP contributes to the insulin response to gastric glucose in mice and suggest that PACAP is involved in the regulation of prandial insulin secretion
Ahrén et al., Ann N Y Acad Sci 2000 : The effects of PACAP on insulin secretion and glucose disposal are altered by adrenalectomy in mice ... We found that in control mice, PACAP potentiated glucose stimulated insulin secretion threefold without affecting glucose disposal ... Adrenalectomy potentiated the augmentation by PACAP27 of glucose stimulated insulin secretion, and in adrenalectomized mice, PACAP27 simultaneously augmented glucose disposal ( elimination rate 2.30 +/- 0.07 % /min vs. 2.56 +/- 0.05 % /min ; p = 0.011 )
Yada et al., Ann N Y Acad Sci 2000 (Diabetes Mellitus, Type 2) : PACAP-38 ( 10 nM ) significantly enhanced insulin induced 2-deoxyglucose uptake by 3T3-L1 adipocytes
Filipsson et al., Diabetes 2001 : PACAP stimulates insulin secretion in a glucose dependent manner, by an effect executed mainly through augmenting the formation of cAMP and stimulating the uptake of calcium
Yamaguchi et al., JOP : Journal of the pancreas 2001 : PACAP ( 1-27 ) ( 0.005-5 microg ) increased the basal insulin secretion by about 15 folds in a dose dependent manner ... The results indicate that PACAP ( 1-27 ) directly enhances the glucose evoked insulin secretion in the endocrine pancreas in anesthetized dogs ... The study suggests that PACAP may play a local facilitating role in insulin secretion in response to glucose loading
Sato et al., Pancreas 2002 : At a concentration of 3.3 mM glucose, PACAP and nicotinamide did not affect glucose dependent insulin secretion, whereas 10 nM GLP-1 stimulated insulin secretion significantly
Rosengren et al., Pflugers Arch 2002 (Insulinoma...) : In intact cells, PACAP-27 ( 100 nM ) stimulated glucose induced insulin secretion by > 60 %
Portela-Gomes et al., Regul Pept 2003 (Diabetes Mellitus, Type 2...) : PACAP significantly potentiated glucose stimulated insulin release in isolated islets of normal but not of GK rats
Yamamoto et al., Diabetes 2003 (Diabetes Mellitus, Experimental) : Overexpression of PACAP in transgenic mouse pancreatic beta-cells enhances insulin secretion and ameliorates streptozotocin induced diabetes
Yamaguchi et al., Can J Physiol Pharmacol 2003 : PACAP ( 1-27 ) ( 0.005-5 microg ) increased basal insulin and glucagon secretion in a dose dependent manner ... In the presence of atropine with an equivalent dose ( 128.2 microg ) of PACAP ( 6-27 ) ( 500 microg ) on a molar basis, the insulin response to PACAP ( 1-27 ) was diminished by about 20 %, while the glucagon response was enhanced by about 80 % ... The study suggests that the endocrine secretagogue effect of PACAP ( 1-27 ) is primarily mediated by the PAC(1) receptor, and that PACAP ( 1-27 ) may interact with muscarinic receptor function in PACAP induced insulin and glucagon secretion in the canine pancreas in vivo
Nakata et al., Nihon Yakurigaku Zasshi 2004 (Diabetes Mellitus, Type 2...) : These results demonstrate that PACAP enhances glucose stimulated insulin secretion in islets, enhances insulin action inadipocytes, and prevents hyperglycemia in diabetic animals
Salehi et al., Regul Pept 2004 : The role of PACAP27 , PACAP38 and VIP in the regulation of insulin release from pancreatic islets isolated from rats previously subjected to total parenteral nutrition (TPN) for 10 days was studied ... PACAP27 , PACAP38 and VIP dose dependently and to the same magnitude potentiated insulin secretion from the islets of freely fed controls in the presence of a substimulatory glucose concentration ( 8.3 mmol/l ) ... The insulin response of islets from TPN treated rats to PACAP27 and PACAP38 was much greater than to VIP
Shintani et al., Regul Pept 2004 (Weight Gain) : PACAP is also involved in insulin secretion from pancreatic beta-cells
Green et al., Peptides 2006 : In contrast to 1.4-1.8-fold concentration dependent stimulation of insulin secretion by PACAP ( 1-27 ), these peptide fragments lacked insulinotropic activity
Persson-Sjögren et al., Neuropeptides 2006 : Both VIP and PACAP enhanced insulin secretion in islets from 4-week-old hyperglycemic ob/ob mice ... The combination of VIP and cholinergic agonists had an additive effect in islets from ob/ob mice, and PACAP combined with carbachol potentiated insulin release in islets from 4-week-old lean mice
Winzell et al., Peptides 2007 : VIP and PACAP stimulate insulin secretion in a glucose dependent manner and they both also stimulate glucagon secretion
Baba et al., Yakugaku Zasshi 2007 (Diabetes Mellitus) : Regarding the peripheral roles of PACAP, we found that PACAP is involved not only in the regulation of insulin secretion in pancreatic islets, but also in the regulation of islet turnover
Ahrén et al., Ann N Y Acad Sci 2008 (Diabetes Mellitus, Type 2) : PACAP stimulates insulin and glucagon secretion
Sakuma et al., Transplant Proc 2009 : Moreover, PACAP increases glucose stimulated insulin release in vitro and in vivo ... Our study indicated that PACAP significantly improved beta-cell viability and survival during culture, and increased insulin secretion in vitro and in vivo
Kulkarni et al., J Endocrinol 1995 : We therefore carried out receptor binding studies on membranes prepared from the glucose-responsive clonal beta-cell line HIT-T15, and also examined the effects of PACAP38 , PACAP27 -- a C-terminal truncated form of the peptide -- and vasoactive intestinal peptide (VIP) on insulin and islet amyloid polypeptide (IAPP) release ... These findings suggest that PACAP and VIP stimulate secretion of insulin and IAPP by binding to a 67 kDa protein on clonal beta-cells and do not alter the transcription of insulin and IAPP under the conditions tested
Yokota et al., Acta Endocrinol (Copenh) 1993 : Under the perfusate glucose concentration of 5.5 mmol/l, 0.1 nmol/l PACAP27 significantly stimulated both insulin and glucagon release ... PACAP 's stimulatory effects on insulin and glucagon release were completely abolished by an equimolar and ten times lower concentration of somatostatin, respectively
Inagaki et al., Proc Natl Acad Sci U S A 1994 : Furthermore, insulin secretion from MIN6 cells is significantly stimulated by PACAP-38
Straub et al., J Biol Chem 1996 : The prolonged effects, but not the acute effects of VIP and PACAP on insulin release were inhibited by low concentrations of wortmannin, a phosphatidylinositol 3-kinase ( PI 3-kinase ) inhibitor ... It is concluded that the acute stimulation of insulin release by VIP and PACAP is mediated by increased cyclic AMP and [ Ca2+ ] i, whereas the sustained release is mediated by a novel wortmannin-sensitive pathway
Klinteberg et al., Endocrinology 1996 : Furthermore, at levels above 0.1 nM, PACAP38 stimulated insulin secretion in a Ca2+ -dependent manner, requiring 0.5 mM glucose
Komatsu et al., Mol Pharmacol 1996 : Under normal Ca ( 2+ ) -containing conditions, PACAP and carbachol stimulated insulin release and markedly potentiated glucose stimulated release ... Thus, simultaneous activation of the beta cell by PACAP , carbachol, and glucose can stimulate insulin release even when [ Ca2+ ] i is not elevated
Inagaki et al., Ann N Y Acad Sci 1996 : Furthermore, insulin secretion from the MIN6 cells is stimulated significantly by PACAP-38 and VIP
Leech et al., Ann N Y Acad Sci 1996 : PACAP and GLP-1 depolarize pancreatic beta cells and stimulate insulin secretion in the presence of glucose
Yada et al., Ann N Y Acad Sci 1996 : Based on these findings, we can draw the following conclusions : ( 1 ) PACAP is localized in pancreatic nerve fibers and islets ; ( 2 ) PACAP in the subpicomolar range stimulates insulin release from islets ; ( 3 ) the stimulation of insulin release is mediated by the cAMP dependent increase in [ Ca2+ ] i in beta cells ; ( 4 ) all the PACAP effects are glucose dependent ; ( 5 ) PACAP is the most potent insulinotropic hormone known, and ( 6 ) the type I PACAP receptor appears to mediate the action of PACAP in the subpicomolar range
Straub et al., Ann N Y Acad Sci 1996 : VIP and PACAP stimulate insulin release by interaction with the VIP-2/PACAP-3 receptor on the beta cell ... This third pathway, which is identified at present only by its sensitivity to low concentrations of wortmannin, plays a major role in the prolonged stimulation of insulin release by VIP and PACAP
Edwards et al., Exp Physiol 1997 : PACAP stimulated the release of insulin and the effect was potentiated during infusions of exogenous glucose
Tornøe et al., Am J Physiol 1997 : PACAP- ( 6-38 ) decreased PACAP induced flow of juice to 59 +/- 7.8 % and insulin secretion and VIP release to 12 +/- 6.8 and 57 +/- 13 %, respectively
Filipsson et al., Am J Physiol 1998 (Insulin Resistance) : PACAP stimulates insulin secretion but inhibits insulin sensitivity in mice ... PACAP-27 and PACAP-38 markedly and equipotently potentiated glucose stimulated insulin secretion, with a half-maximal effect at 33 pmol/kg
Filipsson et al., Regul Pept 1998 : Moreover, both PACAP27 and PACAP38 dose-dependently ( 0.1 nM to 100 nM ) and equipotently stimulated insulin secretion in isolated mouse and rat islets and in HIT-T15 and RINm5F cells ... In mouse, PACAP also stimulated insulin secretion in a subfraction of the isolated islets also at the low dose of 1 fM ... Based on these results, we suggest that PACAP is involved in the neural regulation of insulin secretion
Gonzalez et al., Ann Endocrinol (Paris) 1998 : For instance, PACAP triggers the release of insulin and glucagon, activates steroidogenesis in the adrenal gland and gonads, and stimulates the secretion of most hypophysial cells