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INS — PPP1R12A

Text-mined interactions from Literome

Lee et al., Am J Physiol Cell Physiol 2009 (Diabetes Mellitus, Type 2...) : GK VSMCs had impaired basal and insulin induced Akt phosphorylation as well as increases in basal MYPT1 phosphorylation, inducible nitric oxide synthase (iNOS) expression, and nitrite/nitrate production compared with Wistar-Kyoto controls
Lee et al., Am J Physiol Cell Physiol 2012 (Diabetes Mellitus, Type 2) : We believe the impaired expression of MRIP, and therefore decreased insulin stimulated MRIP/MYPT1 association, in the GK diabetic model may contribute to the impaired insulin mediated vasodilation observed in the diabetic vasculature and provides a novel therapeutic strategy for the treatment of Type 2 diabetes
Chao et al., Journal of proteomics 2012 : The effect of insulin on PPP1R12A phosphorylation is largely unknown ... Insulin stimulated the phosphorylation of PPP1R12A significantly at Ser477, Ser478, Ser507, Ser668, and Ser695, while simultaneously suppressing the phosphorylation of PPP1R12A at Ser509 ( more than 2-fold increase or decrease compared to basal )
Geetha et al., J Endocrinol 2012 (Diabetes Mellitus, Type 2...) : Moreover, kinase inhibition experiments indicated that insulin induced interaction between IRS1 and PPP1R12A was reduced by treatment with inhibitors of phosphatidylinositide 3 kinase, PDK1, Akt, and mTOR/raptor but not MAPK