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INS — TRH

Text-mined interactions from Literome

Gsponer et al., Medicine (Baltimore) 1999 (Acromegaly...) : For screening and follow-up of acromegaly, basal growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels, as well as the paradoxical GH response to TRH ( present in 2/3 acromegalic patients ), could be used as convenient tools, but the most accurate test for diagnosis and prediction of outcome after therapy was GH ( lack of ) suppression during oral glucose tolerance test
Benický et al., Eur J Endocrinol 2000 : Glucose stimulates and insulin inhibits release of pancreatic TRH in vitro ... The aim of our present study was to analyze how glucose and insulin affect TRH secretion by the pancreatic islets ... Our present data showing that glucose stimulates and insulin inhibits pancreatic TRH release are compatible with the possibility that this substance may play a role in glucoregulation
Morley et al., Endocrinology 1979 : TRH ( 10 ng/ml ) by itself had no effect on insulin or glucagon release
Luo et al., J Endocrinol 2004 : TRH increases insulin production in cultured beta-cells, suggesting that it might play a role in regulating pancreatic beta-cell function
Najvirtová et al., Pflugers Arch 2005 : A role of thyrotropin releasing hormone in insulin secretion by isolated rat pancreatic islets
Ao et al., Endocrinology 2005 (Diabetes Mellitus, Type 2) : Altered glucose and insulin responses to brain medullary thyrotropin releasing hormone (TRH) induced autonomic activation in type 2 diabetic Goto-Kakizaki rats ... This unbalanced vago-sympathetic activation by medullary TRH may contribute to the impaired insulin secretion in T2D
Pekary et al., Peptides 2006 (Body Weight) : Phe-TRH inhibits both basal and TRH stimulated insulin release
Vara et al., Acta Endocrinol (Copenh) 1990 : In adult rat islets, TRH inhibits glucose induced insulin release
Cubitt et al., J Biol Chem 1990 (Pituitary Neoplasms) : In cells prelabeled in situ and then permeabilized, TRH stimulated an increase in 3H-labeled Ins phosphates (IPs) in 20 min which was 10 % of 3H radioactivity initially present in lipids
Würzburger et al., Clin Endocrinol (Oxf) 1990 (Diabetes Mellitus, Type 1...) : Effects of improved blood glucose on insulin induced hypoglycaemia, TRH , GnRH and exercise tests in insulin dependent diabetes
Cabell et al., J Anim Sci 1990 (Body Weight) : Consumption of 100 or 1,000 mg TRH increased mean serum concentrations of thyroxine ( T4 ; P less than .001 ), 1,000 mg TRH increased growth hormone ( GH ; P less than .06 ) and 100 or 1,000 mg TRH increased prolactin ( PRL ; P less than .01 ), but insulin ( INS ; P greater than .10 ) was unaffected by TRH
Imai et al., J Biol Chem 1985 (Pituitary Neoplasms) : In cells incubated with 1 mM Bt2cAMP for 16 h, but not for 1 h, the maximum TRH induced increase in Ins-P3 was inhibited to 25 +/- 3.2 % of that in control cells ... Inhibition of TRH induced Ins-P3 formation was also observed in cells treated with 8-bromo-cAMP, cholera toxin, and sodium butyrate for 16 h, and with TRH for 48 h. Inhibition of TRH induced Ins-P3 formation and lowering of TRH receptor concentration caused by Bt2cAMP occurred in parallel with increasing doses of Bt2cAMP ; at 16 h of exposure, half-maximal effects occurred with 0.3 mM Bt2cAMP ... The concentration dependency of TRH induced Ins-P3 formation was the same in control and Bt2cAMP treated cells ; half-maximal effects occurred with 10 nM TRH
Usman et al., Horm Metab Res 1986 (Hypoglycemia) : Based on the fact that human pancreas has thyrotropin releasing hormone (TRH) immunoreactivity and bioactivity, we studied the effect of TRH on peripheral plasma levels of pancreatic glucagon ( IRG ) and insulin ( IRI ) in healthy subjects
Hughes et al., Biochem J 1987 (Pituitary Neoplasms) : We also examined the effects of acute Li+ treatment on the rates of accumulation of these isomers, and demonstrated that Li+ augments TRH mediated accumulation of Ins1P , Ins4P, Ins ( 1,4 ) P2, the presumed Ins ( 4,5 ) P2 and Ins ( 1,3,4 ) P3
Schneider et al., Klin Wochenschr 1978 (Acromegaly...) : The combined insulin induced hypoglycemia/LH-RH/TRH-test is therefore advisable for patients with acromegaly, since GH release as well as other hypophyseal partial functions can be tested
Knudtzon et al., Horm Metab Res 1985 : Involvement of the autonomic nervous system in the in vivo TRH induced increases in the plasma levels of glucagon, insulin and glucose in rabbits ... The effects of TRH `` Roche '' on the plasma levels of glucagon, insulin and glucose can not be explained by increases in the plasma levels of catecholamines
Fedotov et al., Probl Endokrinol (Mosk) 1985 : A study was made of the TRH effect on insulin and glucagon secretory function of a 4-day neonatal rat pancreatic islet cell culture ... TRH stimulated insulin and glucagon secretion within the range of the above doses
Faure et al., Can Med Assoc J 1977 (Acromegaly...) : Effect of somatostatin on thyrotropin, prolactin, growth hormone and insulin responses to thyrotropin releasing hormone and arginine in healthy, hypothyroid and acromegalic subjects
Kazumi et al., Acta Endocrinol (Copenh) 1982 : These results suggest that TRH may be localized to the B cells of pancreatic islets, and that the marked reduction in TRH in diabetic pancreases is not a metabolic consequence of insulin deficiency
Mitsuma et al., Horm Metab Res 1983 : Effects of insulin on thyrotropin releasing hormone from frog skin ... Insulin and noradrenaline stimulated TRH release from frog skin in a dose related manner
Kraft et al., Horm Metab Res 1984 (Brain Neoplasms...) : After subtotal removal of the tumor, basal PRL was still undetectable, but could be stimulated moderately by insulin induced hypoglycaemia or TRH
Knudtzon et al., Horm Metab Res 1981 : Moreover, TRH immunological and biological activities have been demonstrated in the pancreatic islets, but experiments with isolated rat pancreas have failed to show any direct stimulatory effect of TRH on glucagon and insulin release
Kulkarni et al., Endocrinology 1995 (Insulinoma...) : Pyroglutamyl-phenylalanyl-proline amide attenuates thyrotropin releasing hormone stimulated insulin secretion in perifused rat islets and insulin secreting clonal beta-cell lines ... TRH at 10 nM potentiated [ 0.5 +/- 0.1 ( control ) vs. 0.8 +/- 0.1 ( TRH ) pmol/10 ( 6 ) cells per 120 min ; mean +/- SEM ; n = 6 ; P < 0.001 ; n = 15 ], whereas EFP from 1 nM upwards suppressed glucose stimulated insulin secretion [ 0.8 +/- 0.1 ( control ) vs. 0.5 +/- 0.1 ( EFP ) pmol/10 ( 6 ) cells per 120 min ; P < 0.001 ; n = 12 ) in the cell lines ... Further, EFP reversed TRH stimulated insulin release
Banks et al., Methods Find Exp Clin Pharmacol 1995 (Adenoma...) : Neither FLA99 ( 100, 300 and 1000 microM ) nor EWP840 ( 100 microM ) produced obvious effects on the Ins ( 1,4,5 ) P3 response to TRH stimulation ... Higher concentrations of EWP840 ( 300 and 1000 microM ) abolished the Ins ( 1,4,5 ) P3 response to TRH stimulation
Wagner et al., Biochem J 1993 : The intracellular Ca2+ pool necessary for BAY K-induced oscillations was not the same Ins ( 1,4,5 ) P3-sensitive pool stimulated by thyrotropin releasing hormone (TRH), because the TRH stimulated Ins ( 1,4,5 ) P3-induced [ Ca2+ ] i spike and the BAY K 8644 induced oscillations were differentially sensitive to chelation of extracellular Ca2+ and thapsigargin
Lockhart-Ewart et al., Diabetes 1976 : The effects of thyrotropin releasing hormone , luteinizing hormone releasing hormone, substance P, somatostatin, and a partially purified hypothalamic extract on insulin secretion were tested both in vitro and in vivo
Judd et al., Aust N Z J Med 1976 (Acromegaly...) : Individually, insulin induced hypoglycaemia, thyrotrophin releasing hormone (TRH) and gonadotrophin releasing hormone (GnRH) have proved to be reliable stimuli for the release of the various pituary hormones
McCarty et al., Med Hypotheses 1995 (Diabetes Mellitus...) : I propose that insulin , acting centrally as a signal of carbohydrate availability, promotes TRH secretion by inhibiting release of neuropeptide Y in the paraventricular nucleus
van Haasteren et al., J Endocrinol 1997 (Diabetes Mellitus, Experimental) : Moreover, insulin had a positive effect on TRH release in vitro
Chen et al., J Auton Nerv Syst 1998 (Diabetes Mellitus...) : Centrally administered TRH induced insulin secretion is impaired in the Otsuka-Long-Evans-Tokushima Fatty rats, a model of spontaneous non-insulin dependent diabetes mellitus
Duntas et al., Thyroid 1998 (Obesity) : Oral TRH , coupled with OGTT in both controls and obese patients, led to a significant inhibition of BG ( p < 0.01 ), of CP ( p < 0.001 ), and of INS ( p < 0.001 ) during the first hour of administration, and afterward, there was only a very slight increase, compared with levels after only OGTT treatment