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CCK — JUN
Text-mined interactions from Literome
Gukovsky et al., Am J Physiol Gastrointest Liver Physiol 2003
(Pancreatitis, Alcoholic) :
Curcumin also blocked
CCK induced NF-kappaB and
AP-1 activation in isolated pancreatic acini
Guo et al., Am J Physiol Gastrointest Liver Physiol 2012
:
When signaling pathways were evaluated,
CCK stimulation
increased c-Jun expression, JNK and ERK activity, and
AP-1 activation ... Chemical inhibitors of JNK and ERK pathways, dominant negative JNK and c-Jun, and c-Jun shRNA significantly inhibited CCK induced DNA synthesis,
CCK induced
AP-1 activation, and cyclin D1 expression
Oiry et al., Mol Pharmacol 1997
:
To confirm that
CCK ( B ) receptors are
involved in
AP-1 response, we investigated the CCK-8 effect on interleukin-2 expression, a natural endogenous gene regulated by several factors, including AP-1
Tateishi et al., Pancreas 1998
(Carcinoma, Ductal, Breast...) :
c-Jun amino-terminal kinases (JNKs) of 46 kDa ( p46jnk ) and 55 kDa ( p55jnk ) were also
activated by
CCK-8 and increased the phosphorylation of c-Jun ...
CCK-8 at 10 ( -7 ) M
induced 1.5-fold increases in the phosphorylation of MAPK and of
c-Jun by JNKs, respectively