Gene interactions and pathways from curated databases and text-mining

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F2R — TNF

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Shinohara et al., Cytokine 2002 : The stimulation with 100 U/ml TNFalpha transiently down-regulated the PAR-1 mRNA expression to approximately 0.3-fold of the basal level at 30 min, but it rebounded 3-fold above the basal level at 6h, and again decreased to 0.5-fold of the basal level at 12h, and finally returned to the basal level at 24h
Lang et al., Invest Ophthalmol Vis Sci 2003 : HCE-T expression of cytokines ( IL-6, IL-8, and TNFalpha ) in response to activation of PAR-1 and -2 was measured by quantitative RT-PCR and ELISA