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GPR15 — TNF
Text-mined interactions from Literome
Pascual et al., Am J Physiol Lung Cell Mol Physiol 2001
(MAP Kinase Signaling System) :
In this study, we examined the mechanisms by which IL-1 beta and
TNF-alpha affect inhibition of cell growth,
G protein coupled receptor ( GPCR ) desensitization, and the recently reported adenylyl cyclase sensitization in human airway smooth muscle ( HASM ) cultures
Croitoru-Lamoury et al., Glia 2003
:
Moreover,
TNFalpha and IL-1beta significantly
increase BOB/GPR15 , CCR2, and V28/CX3CR1 mRNA levels in both models
Chen et al., J Appl Physiol 2003
:
We previously reported that
TNF-alpha , a cytokine involved in asthma,
augments G-protein coupled receptor ( GPCR ) agonist evoked calcium responses in cultured ASM cells
Suo et al., J Neurosci 2004
(Alzheimer Disease...) :
We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above, Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release, and at subthreshold doses, Abeta indirectly potentiated
TNF-alpha release
induced by certain
G-protein coupled receptor ( GPCR ) activators
Yeh et al., Biochemistry 2011
(Chronic Disease...) :
Here, we report novel strategies for successfully retargeting BoNTs, and also tetanus neurotoxin ( TeNT ), to primary human blood monocyte derived macrophages where
BoNT/B inhibited the release of
tumor necrosis factor-a , a cytokine that plays a key role in inflammation