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HDAC4 — IL2

Text-mined interactions from Literome

Matsuoka et al., Biochem Pharmacol 2007 : Disruption of HDAC4/N-CoR complex by histone deacetylase inhibitors leads to inhibition of IL-2 gene expression ... We therefore focused on the role of HDAC4/N-CoR complex in the transcriptional regulation of IL-2 ... Here, we report that HDAC4 plays an essential role in IL-2 promoter activation, and that the formation of the HDAC4/N-CoR complex, which is closely related to HDAC4-enzymatic activity, might be involved in HDAC inhibitor mediated inhibition of IL-2 gene expression
Nayak et al., J Biol Chem 2009 : Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase
Rehni et al., Naunyn Schmiedebergs Arch Pharmacol 2012 (Opioid-Related Disorders...) : The present study has been designed to investigate the effect of selective inhibitors of histone deacetylase and/or N-acetyl-Asp-Glu-Val-Asp-al ( Ac-DEVD-CHO ), a selective interleukin-1ß converting enzyme inhibitor , on the development of naloxone induced opioid withdrawal syndrome both in vitro and in vivo and the effect of histone deacetylase inhibition on histone H3 acetylation in brain