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CCL20 — SPP1

Text-mined interactions from Literome

Shiba et al., Biochem Biophys Res Commun 2003 : In the present study, we investigated effects of MIP-3alpha and BD-2 on the DSPP and osteopontin (OPN) gene expression in cultures of human pulp derived fibroblastic cells ( HP cells ) ... MIP-3alpha and BD-2 increased OPN mRNA levels very slightly
Li et al., PloS one 2013 : Meanwhile, Osteopontin (OPN), a broadly expressed pleiotropic cytokine, has been implicated in GD through inducing Th1 involved response to enhance the production of proinflammatory cytokines and chemokines, but little is known about the role of OPN in regulating CCL20 and IL-17 signaling ... This study sought to explore the possibility of CCL20 level as a biomarker for GD, as well as investigate the role of OPN in regulating CCL20 production ... Moreover, we demonstrated that recombinant OPN and plasma from untreated GD patients increased the expression of CCL20 in CD4+T cells, which could be blocked by OPN antibody ... Furthermore, we found that the effect of OPN on CCL20 expression was mediated by ß3 integrin receptor, IL-17, NF-?B and MAPK pathways ... These results demonstrated that CCL20 might serve as a biomarker for GD and suggested the possible role of OPN in induction of CCL20 expression