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SPP1 — TNFSF11

Text-mined interactions from Literome

Kaku et al., J Periodontal Res 2005 : RANKL is one of the essential factors for osteoclast maturation and induces the constitutive induction of intracellular osteopontin in vitro
Walker et al., Bone 2010 (Tooth Migration) : Osteopontin is required for unloading induced osteoclast recruitment and modulation of RANKL expression during tooth drift associated bone remodeling, but not for super-eruption ... Together, our studies suggest that increased OPN expression during unloading induced drifting of teeth enhances localized RANKL expression and osteoclast activity on drift-direction alveolar bone surfaces via extracellular matrix signaling pathways