◀ Back to LEP

LEP — SST

Text-mined interactions from Literome

Tan et al., Clin Endocrinol (Oxf) 2001 (Acromegaly) : We have evaluated the effect of Sandostatin LAR on leptin levels in acromegalic patients since there are recent data to suggest that somatostatin , in addition to its GH lowering effect, also reduces serum leptin levels in humans
Goïot et al., Gastroenterology 2001 : The effects of leptin on gastrin messenger RNA ( mRNA ), plasma gastrin, gastric acid in vivo in the rat, and on somatostatin and gastrin secretions by isolated antral cells were determined in vitro ... Isolated antral cells specifically bound [ ( 125 ) I ] -leptin , and addition of leptin to these cells inhibited the release of somatostatin and increased the release of gastrin
Watanobe et al., J Neurosci 2002 : Leptin regulates growth hormone releasing factor, somatostatin , and alpha-melanocyte stimulating hormone but not neuropeptide Y release in rat hypothalamus in vivo : relation with growth hormone secretion ... However, no previous study examined in vivo whether leptin affects the secretion of GH-releasing factor (GRF), somatostatin ( SRIH ), and some other closely relevant neurohormones in the hypothalamus
Rigamonti et al., Metabolism 2012 (Obesity...) : Somatostatin ( SRIF ) inhibits circulating levels of adiponectin and leptin in lean ( LN ) subjects, but the effect of a SRIF infusion on these adipokines, including TNF-a, in OB is to date unknown
Perianes-Cachero et al., Neurochem Int 2012 : As leptin and its receptors are expressed in the hippocampus and somatostatin ( SRIF ), an orexigenic neuropeptide, may inhibit leptin mediated suppression of food intake in other brain areas, we asked whether chronic leptin infusion induces changes in the hippocampal somatostatinergic system and whether these modifications are involved in leptin mediated effects
Quintela et al., Endocrinology 1997 : Leptin inhibits in vitro hypothalamic somatostatin secretion and somatostatin mRNA levels ... In order to further unravel the mechanisms by which leptin acts, we have studied the effect of leptin on in vitro somatostatin synthesis and secretion ... Finally, leptin ( 3x10 ( -8 ) M M ) also inhibited low glucose ( 1.1 mM ) induced-somatostatin secretion in perifused adult hypothalami
Donahoo et al., J Clin Endocrinol Metab 1997 : Therefore both isoproterenol and somatostatin reduce plasma leptin in humans
Leclercq-Meyer et al., Mol Cell Endocrinol 1998 (Body Weight) : Failure of human and mouse leptin to affect insulin, glucagon and somatostatin secretion by the perfused rat pancreas at physiological glucose concentration
Tannenbaum et al., Endocrinology 1998 (Body Weight) : The results suggest that the GH-releasing activity of leptin is mediated , at least in part, by an inhibition of hypothalamic somatostatin release