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NOTCH4 — TLR1
Text-mined interactions from Literome
Hu et al., Immunity 2008
:
This Hes1- and Hey1 mediated feedback inhibitory loop was abrogated by interferon-gamma (IFN-gamma), which blocked
TLR induced activation of canonical
Notch target genes by inhibiting Notch2 signaling and downstream transcription
Zhang et al., J Biol Chem 2012
(Inflammation...) :
It is widely accepted that
TLR signaling can
activate Notch pathway ; however, whether full activation of Notch signaling can feedback modulate TLR signaling pathway so as to control inflammation response remains unclear